Major Depressive Disorder Clinical Trial
Official title:
A Randomized, Open-label, Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide
This study is being done to look at how well people respond to two different drug treatments for depression. Clinically, people can respond differently to different treatments for reasons which are not always clear. Some research shows that people with a family history of bipolar disorder or completed suicide may react differently to standard medications used to treat depression than those without a family history. The investigators need to know if these drugs are effective to use in patients with depression who have a family history of bipolar disorder or completed suicide.
Lithium is a mood stabilizing drug that has been used to treat people with both bipolar
disorder and depression for the last 50 years. It is available to the public by prescription
in Canada and has been used by millions of people world wide. Paroxetine is an antidepressant
drug that has been used to treat people with depression for the past 10 years. It is also
available to the public by prescription in Canada and has been used by millions world wide.
Subjects who join the study, will be given one of the study drugs, either lithium or
paroxetine.
Subjects will be randomized "like the flip of a coin" to receive either lithium or
paroxetine.
The study drug will be taken once a day by mouth and the daily dose adjusted to find the
right dose for the subject. The study drug will be taken for a 6-week period and subjects
will be assessed by the research team on a weekly basis.
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