Major Depressive Disorder Clinical Trial
Official title:
The Study of Morning and Nocturnal Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder
One of the main points in the biological trends is, the circadian rhythm and disturbance in
this cycle, which cause mood disorders and irregularity in this bio clock, to get depression.
The pineal gland with the precise regulation of circadian rhythm of melatonin regulates the
brain haemostasis. The abnormal function of this gland gives rise to psychiatric disorders.
In the period of youth and early of middle-age cause biochemical changes and disturbance in
biorhythm including melatonin secretion.
This process can change the peak of melatonin phase. In addition, a decrease in the level of
serum melatonin, can change the function of immune system of depressed patients. This
function facilitates the process of cancerous cell formation and tumor growth.
With respect to the conflicting results and that the positive and negative roles of melatonin
in the creation of depression is unknown, the aim of this study was to compare the morning
and nocturnal serum melatonin rhythm levels in the patients with Major Depressive Disorder.
The second purpose was to measure the morning and nocturnal serum melatonin levels in the
depressed and healthy men and women.
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