Major Depressive Disorder Clinical Trial
Official title:
A Comparison of Cognitive and Dynamic Therapy for MDD in Community Settings
The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic
psychotherapy, with cognitive therapy for the treatment of depression in community mental
health consumers.
Hypothesized mediators of treatment will also be examined.
The goal of this study is to conduct a randomized, comparative, non-inferiority clinical
trial that tests the hypothesis that a widely used form of manualized dynamic psychotherapy
(supportive-expressive psychodynamic therapy) is not inferior to cognitive therapy when
implemented in community mental health settings for the treatment of major depressive
disorder (MDD). The specific aims are (1) to conduct a randomized non-inferiority trial to
compare supportive-expressive psychodynamic therapy and cognitive therapy for patients with
MDD and (2) to assess the comparative effectiveness of supportive-expressive psychodynamic
therapy and cognitive therapy on secondary measures of symptoms, patient functioning, and
quality of life.
Patient mediators of outcome will also be examined through an additional grant awarded to
Paul Crits-Christoph, Ph.D. This grant was funded by the National Institutes of Mental
Health - RO1MH092363-01. This grant is entitled:"The mechanisms of cognitive and dynamic
therapy in community settings."
Recruitment will occur solely through community mental health clinics in and around
Philadelphia.
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