Major Depressive Disorder Clinical Trial
Official title:
Epigenetic Regulation of Brain-Derived Neurotropic Factor (BDNF) in Patients With Major Depression
The investigators will (1) detect the associations between brain-derived neurotrophic factor (BDNF) DNA methylation, histone modification, depressive symptoms, suicidal behavior and antidepressant responses in major depressive disorder (MDD) patients, (2) check the correlation between blood BDNF protein and RNA and BDNF rs6265 gene, and (3) discuss the possible mechanisms of epigenetic regulation of BDNF in Taiwanese major depressive patients.
Brain-derived neurotrophic factor (BDNF) had been chosen as a candidate gene for a
development of major depressive disorder (MDD). BDNF had been reported to have an important
role on neuronal plasticity, axonal growth and connectivity, and participating in the local
response to various types of neuronal stressors. BDNF also influences the differentiation of
neurons.
In the past studies, the investigators had found that major depressive women had lower serum
BDNF protein levels than healthy controls, and their BDNF levels became significantly
increased after antidepressant treatments. In addition, some authors had found that reduced
expression of BDNF was noted in postmortem brain of completed suicide subjects. Suicidal
major depressive patients also had lower plasma BDNF levels than non-suicidal major
depressive patients. These findings suggested that BDNF might play an important role in the
suicidal behavior.
However, in past studies, the results did not fully explain why major depressive patients
with same genotypes had different clinical expression, including the severity of depression,
with/without suicide, and the treatment response. Recently, some papers found that there
were relationships between epigenetic regulation, including DNA methylation and histone
modification, and psychopathology of major depression. Therefore, we try to investigate the
relationships between epigenetic regulation of BDNF and major depression.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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