Major Depressive Disorder Clinical Trial
Official title:
Efficacy and Safety of Augmentation of Creatine for the Patients With Major Depressive Disorder
Given 1) the established safety with short-term or long-term supplementation of Cr, 2) its
potential usefulness in improving brain energy metabolism, 3) the reported abnormality in
brain energy metabolism in MDD subjects, and 4) plausible association between depression and
inflammatory mediators, we hypothesize that oral Cr augmentation will help reduce symptoms in
MDD patients as well as normalize a deficit in brain energy metabolism and that improvement
of MDD and brain energy metabolism will be correlated with inflammatory mediators changes.
In this study, we plan to conduct an randomized, double-blind, placebo-controlled
augmentation study with creatine in addition to escitalopram. We will assess the efficacy and
safety of the Cr augmentation and evaluate changes relevant to brain energy metabolism and
inflammatory mediators.
n/a
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