Brain Imaging of Psychotherapy for Depression

Major Depressive Disorder Clinical Trial

Official title:

Brain Imaging of Psychotherapy for Depression (Includes, "Reward System Recovery Following Behavioral Activation Therapy in Depression")

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00609453
• Other study ID #: 05-2605
• Secondary ID: NIMH R03 MH07814
• Status: Completed
• Phase: N/A
• First received: January 24, 2008
• Last updated: October 5, 2012
• Start date: October 2006
• Est. completion date: January 2008

Study information

• Verified date: October 2012
• Source: University of North Carolina, Chapel Hill
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: January 2008
• Est. primary completion date: January 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 55 Years

Eligibility

Inclusion Criteria:

• For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder

• For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion Criteria:

• A history of serious head injury or neurological disease or psychosis

• Current use of psychoactive medications

• Factors that could affect MRI safety including current or planned pregnancy

• For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Major Depressive Disorder

Intervention

Behavioral:
• Brief Behavioral Activation Treatment for Depression
Weekly individual therapy sessions

Locations

Country	Name	City	State
United States	Duke-UNC Brain Imaging and Analysis Center	Durham	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
University of North Carolina, Chapel Hill

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hamilton Depression Inventory		three times over 12 weeks	No
Primary	Functional Magnetic Resonance Imaging		twice in 12 weeks	No