Major Depressive Disorder Clinical Trial
Official title:
Neural Correlates of Emotional Processing in Depressed and Remitted Bipolar and Unipolar Depressed Subjects: An fMRI Investigation
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control subjects. Depressed patients will be treated with a combination of fluoxetine and olanzapine and undergo MRI scans before, during, and after pharmacotherapy.
The purpose of this study is to further characterize the neural correlates of affective
processing in BD and MDD subjects using fMRI. Subjects who meet criteria for a major
depressive episode in the context of BD (n=15); MDD (n=15) and a group of psychiatrically
unaffected control subjects (CS, n=15) will undergo four fMRI scans while experiencing a
temporary mood induction through the presentation of affective imagery from the
International Affective Picture System (IAPS). Both BD and MDD subjects will receive the
same combination pharmacotherapy to treat the depression, with fMRI data acquired before,
and 1, 3, 6 weeks following pharmacotherapy initiation. Positive, negative, and neutral
affective visual stimuli will be presented in a blocked design.
Comparison(s): The effects of time and group will be analyzed in factorial models. Regions
of interest that demonstrate significant group-by-time interactions will be further
correlated with self-report and clinician-rated psychometric indices.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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