Lung Cancer Clinical Trial
Official title:
Effects of Epidural Anesthesia-analgesia on Long-term Survival in Patients After Lung Cancer Surgery: A Randomized Controlled Trial
Available studies suggest that regional anesthesia-analgesia may decrease the occurrence of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking. The purpose of this randomized controlled trial is to investigate the effect of epidural anesthesia-analgesia on recurrence-free survival in patients undergoing lung cancer surgery.
Lung cancer is increasing and is the leading cause of cancer death. Surgical resection is the
mainstay of treatment for early stage non-small cell lung cancer. However, long-term survival
after lung cancer surgery is far from optimal, and cancer recurrence or metastasis is the
main reason leading to cancer death in these patients.
The development of cancer recurrence/metastasis largely depends on the balance between
tumor-promoting factors and immune function of the body. Studies showed that surgical
manipulation releases cancer cells into circulation; and stress response induced by surgery
inhibits the cell-mediated immunity. In addition, volatile anesthetics and opioids may also
aggravate immunosuppression and potentially worsen long-term outcome. On the other hand,
regional anesthesia can blunt surgical stress and reduce anesthetic consumption. These
effects may help to preserve immune function and reduce recurrence/metastasis. However,
existing evidences are insufficient to draw conclusion in this topic.
The purpose of this randomized controlled trial is to test the hypothesize that regional
anesthesia-analgesia may reduce recurrence/metastasis and improve long-term survival in
patients after lung cancer surgery.
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