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Knee Osteoarthritis clinical trials

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NCT ID: NCT05378815 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Platelet-rich Plasma in Symptomatic Knee Osteoarthritis

PIKOA
Start date: June 1, 2024
Phase: N/A
Study type: Interventional

Intro: Platelet rich plasma (PRP) is largely used in various musculoskeletal disorders such as chronic tendinopathies but also osteoarthritis (OA). Several therapeutic trials evaluating the effectiveness of intra-articular PRP injections in knee OA as well as meta-analyses have already been published. Most of them have compared PRP to Hyaluronic Acid (HA). Their design was very heterogeneous in terms of PRP characteristics and injection protocol. Moreover, the number of patients included was often very low. Only few studies have compared PRP to placebo (physiological serum) and presented the same methodological limitations (limited number of patients, heterogeneous protocols in terms of number and frequency of injections, characteristics of PRP, etc.). Given the insufficient level of evidence related to these limitations, PRP injections are not recommended in the treatment of symptomatic knee OA by the main scientific societies such as American College of Rheumatology (ACR), Osteoarthritis Research Society International (OARSI), American Academy of Orthopedic Surgeons (AAOS) and French Society of Rheumatology (SFR). Experts in the field agree on the need for a placebo-controlled trial with hihg methodological quality and simple design in order to conclude with a good level of evidence to the benefit or not of this new therapeutic weapon in symptomatic knee osteoarthritis of moderate radiographic severity.

NCT ID: NCT05376995 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Effect of Graston Technique Versus MET on Improving Hamstring Flexibility and ADLS in Knee Osteoarthritis

Start date: May 2022
Phase: N/A
Study type: Interventional

The objective of this study is to determine the comparison of Graston technique versus muscle energy technique to improve hamstring flexibility and ADL among patient of knee O.A.

NCT ID: NCT05352477 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Balneotherapy With Acquabios Thermal Water in Knee Osteoarthritis

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

The aim of the study is the evaluation of the effect of balneotherapy with Acquabios bicarbonate-alkaline-sodium thermal water in ameliorating some signs and symptoms of knee osteoarthritis in human subjects suffering from this disease

NCT ID: NCT05316792 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Evaluation of Femoral Cartilage Thickness After Treadmill and Tartan Track Walking

Start date: September 15, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to measure and compare the femoral cartilage deformation after walking on the treadmill and tartan floor in patients with knee osteoarthritis (OA) and healthy volunteers.

NCT ID: NCT05303766 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Radiofrequency Ablation in the Pain Management of Knee Osteoarthritis

Start date: April 2022
Phase: N/A
Study type: Interventional

The aim of this study is to assess the safety and efficacy of radio frequency thermo-coagulation on the genicular nerve (RFTGN) and intra-articular pulsed radio frequency (IAPRF) for Knee Osteoarthritis (KOA) to improve physical activity , range of joint movement , pain intensity and quality of life.

NCT ID: NCT05277883 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Influence of Knee Alignment and Pelvis Rotation on Accuracy of Radiograph Measurements Before Total Knee Arthroplasty

Start date: December 2022
Phase:
Study type: Observational

The aim of this study is to determine the accuracy of long leg standing X-rays with respect to coronal alignment of the knee.

NCT ID: NCT05263856 Not yet recruiting - Knee Osteoarthritis Clinical Trials

The Effect of Laser Acupuncture Intervention to the Prognosis After TKR Surgery

Start date: March 7, 2022
Phase: N/A
Study type: Interventional

This study protocol is mainly focus on the patients, who suffer pain, swelling, or range of motion limitation after total knee replacement (TKR) surgery procedure,would be relieved by use non-invasive laser acupuncture to stimuli on 1) the reflection areas of ear acupuncture point associated knee and pain mechanism; 2) muscle trigger points around knee joint with adequate frequency and energy power to stimuli.

NCT ID: NCT05211544 Not yet recruiting - Knee Osteoarthritis Clinical Trials

The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis

Start date: January 21, 2022
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is the most common degenerative joint disease with pathological structural and functional disorders all over the world. 27 million patients diagnosed with osteoarthritis in the USA alone.(1-2)

NCT ID: NCT05206474 Not yet recruiting - Knee Osteoarthritis Clinical Trials

To Evaluate the Performance and Safety of the Medical Device IRADYN in Subjects With Osteoarthritis of the Knee

IRADYN
Start date: March 7, 2022
Phase: N/A
Study type: Interventional

The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN) formulation.

NCT ID: NCT05178615 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Investigation of the Effect of Preoperative Education on Postoperative Outcomes in Total Knee Arthroplasty Patients

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Total knee arthroplasty surgery is a common surgical procedure used in the treatment of patients in the end stages of osteoarthritis. Arthroplasty surgery is a process that creates physical and psychological stress on the patient. Preoperative education can reduce anxiety and improve postoperative outcomes. In the studies on education in the literature, it is seen that there are trainings in the form of seminars, trainings made with video recordings, trainings in the form of brochures. Studies in the literature have shown that training given synchronously (live) by a healthcare professional is more effective in reducing anxiety in one-on-one or small-person groups. Less anxiety does not significantly reduce pain levels, but improves patients' ability to cope with pain and increases their perception of preparedness. Together, these two factors can improve patients' overall experience by increasing their sense of control and comfort.