Clinical Trials Logo

Clinical Trial Summary

The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN) formulation.


Clinical Trial Description

Of all osteoarthritis' localization into human body, knee OA represents the most common OA localization. On 2014 the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) has suggested as first step of pharmacological treatment for knee osteoarthritis (OA) a background therapy with chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs). In this class of natural compounds, hyaluronic acid (HA) has evidenced its efficacy after intra-articular (IA) administration in patient with mild to moderate knee OA . The filler used in this clinical investigation is using polymerised polynucleotides (PDRN) that has hydrophilic properties of polyanions; therefore, it can bind water molecules and provide a moisturising and lubricant effect. Its viscoelastic properties allow it to compensate for the loss of synovial fluid viscosity in the event of degenerative or trauma joint alterations. These actions reduce the mechanical stress on joints, thereby decreasing friction. This improves joint function and movement with significant relief of pain commonly associated with this problem. Moreover, the enzymatic degradation of the polynucleotide chain releases nucleotides into the synovial cavity. These nucleotides can bind water molecules and share the same viscoelastic properties as the entire chain, helping extend the duration of the effect. The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN) formulation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05206474
Study type Interventional
Source I.R.A. Istituto Ricerche Applicate S.p.A.
Contact Dioniso Franco Barattini, MD
Phone +40774012684
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date March 7, 2022
Completion date October 1, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT04651673 - Prescribed Knee Brace Treatments for Osteoarthritis of the Knee (Knee OA)
Active, not recruiting NCT04043819 - Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis Phase 1
Recruiting NCT05160246 - The Instant Effect of Kinesiology Taping in Patients With Knee OA N/A
Completed NCT05014542 - Needling Techniques for Knee Osteoarthritis N/A
Active, not recruiting NCT03472300 - Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Recruiting NCT04017533 - Stability of Uncemented Medially Stabilized TKA N/A
Completed NCT04779164 - The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis N/A
Recruiting NCT04006314 - Platelet Rich Plasma and Neural Prolotherapy Injections in Treating Knee Osteoarthritis N/A
Enrolling by invitation NCT04145401 - Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Active, not recruiting NCT03781843 - Effects of Genicular Nerve Block in Knee Osteoarthritis N/A
Recruiting NCT05324163 - Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis Phase 3
Recruiting NCT04749628 - Cannabidiol for Bilateral Total Knee Arthroplasty Phase 4
Completed NCT04589858 - Effect of Manual Therapies With Supervised Exercise Protocol on Pain and Functional Disability in Patients With Knee OA N/A
Recruiting NCT04592562 - Genicular Artery Embolization to Reduce Pain Associated With Unilateral Mild to Moderate Osteoarthritis N/A
Not yet recruiting NCT05374330 - Electroacupuncture Treatment for Those With End Stage Knee Osteoarthritis on a Total Knee Arthroplasty Waitlist N/A
Not yet recruiting NCT05062499 - The Effects of Home Use of Transcutaneous Electrical Nerve Stimulation on People With Knee OA and or Chronic Knee Pain N/A
Not yet recruiting NCT04331990 - The Distraction of Knee Joint to Alleviate osteoArthritic Pain (DiKAP) Trial N/A
Not yet recruiting NCT03825965 - Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT Phase 3
Not yet recruiting NCT04257682 - Regional Anesthesia in Total Hip and Knee Arthroplasty Phase 4
Not yet recruiting NCT04040764 - Uncemented Tritanium TKR vs Cemented Triathlon TKR N/A