Ischemic Stroke Clinical Trial
Official title:
Prognostic Value of Cardiac and Renal Markers in the Acute Phase of Ischemic Stroke or Transient Ischemic Attack :Albuminuria-Brain Natriuretic Peptide-Cystatine C in Stroke
Patients with stroke or transient ischemic attack (TIA) are at high risk of poor outcome, recurrence of cardiovascular events or vascular death.Until now, no reliable predictive biological marker could be identified in the acute phase of stroke.We hypothese that, in the acute phase of ischemic stroke or TIA, the increase of cardiac ( brain natriuretic peptide, BNP) or renal markers (albuminuria, cystatin C)might predict recurrence of cardiovascular events or vascular death. We want to assess which one of these markers has the best prognosis value , in a prospective study of 300 stroke patients followed during 3 years.
Patients with ischemic stroke or TIA will be included in the 48 hours following the onset of
symptoms, in 3 university hospitals.For each patient will be collected
- 1 blood sample for the BNP measure in pg/ml
- 1 blood sample for the Cystatin C measure in mg/l
- 2 urinary samples to measure the albumine/creatinine ratio, at inclusion and 5 days
after the inclusion, and to study the variation of albuminuria in micrograms/min.
The clinical follow-up will be organized during 3 years. The following events will be
notified: poor outcome (defined with the Barthel and Rankin scores), recurrence of
cardiovascular or cerebrovascular events, vascular death.
After adjustment on the main clinical prognosis factors, we want to determine wich one of
these markers has the best prognosis significance and allows to identify in the acute phase
the "high-risk" patients, in order to intensify individual treatment and secondary
prevention.
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