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Infertility clinical trials

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NCT ID: NCT03250195 Terminated - Fertility Disorders Clinical Trials

Non-invasive Detection of Male Infertility With FDG-PET/MRI (Spectroscopy and DWI)

Start date: August 7, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to examine the value of the new MRI techniques (spectroscopy and DWI), and FDG-PET in prognostication of male infertility.

NCT ID: NCT03181685 Terminated - Infertility Clinical Trials

Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles

Start date: December 20, 2016
Phase: Phase 4
Study type: Interventional

This randomized, controlled, prospective, crossover, open-label, two-treatments, two-period trial aimed to evaluate the preference expressed by the patient concerning the subcutaneous administration of progesterone versus the vaginal one. The couples, scheduled for performing 2 In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) cycles will be randomized to receive, as luteal phase supplementation, Pleyris 25 milligram (mg) (a single subcutaneous administration per day) or Prometrium 200 mg (3 vaginal administrations per day).

NCT ID: NCT03173885 Terminated - Infertility Clinical Trials

Investigating the Cryopreserved Blastocyst's ImplantatiOn Potential After Genetic Screening

BIOPS
Start date: May 18, 2017
Phase: N/A
Study type: Interventional

This is a two-arm parallel group randomized controlled trial at the Department of Reproductive Medicine at Ghent University Hospital. Women >=18 and <37 years of age undergoing their first or second IVF/ICSI treatment, with at least 2 good quality blastocysts remaining after fresh embryo transfer will be randomized to either transfer of a cryopreserved blastocyst selected based on morphology (standard treatment arm) or transfer of a cryopreserved blastocyst selected based on PGS and morphology (intervention treatment arm).

NCT ID: NCT03164551 Terminated - Infertility Clinical Trials

TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment

TICON
Start date: April 16, 2018
Phase: Phase 4
Study type: Interventional

The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development and automated scoring using a predictive algorithm.

NCT ID: NCT03115320 Terminated - Infertility Clinical Trials

Frozen-thawed Embryo Transfer in a Naturally Stimulated Cycle: Does hCG Triggering Bring Any Advantage in Comparison to Testing LH Surge With Home Tests?

Start date: January 2017
Phase: Phase 4
Study type: Interventional

The primary aim of this study is to find out if ovulation triggered with hCG provides any additional benefit in comparison to spontaneous LH surge measured with the home test when transferring frozen-thawed embryo in a naturally stimulated cycle.

NCT ID: NCT03088735 Terminated - Infertility, Female Clinical Trials

Transfer Strategy in an Oocyte Donation Programme

Start date: April 5, 2017
Phase: N/A
Study type: Interventional

It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3). Without this activation, the embryo can not continue its development. Therefore, it has been suggested that extended culture to blastocyst stage could be an option to identify and better select embryos that have been able to carry out this activation. The purpose of this study is to compare cumulative pregnancy and live birth rates following transfer of cleavage embryos or blastocysts.

NCT ID: NCT02991950 Terminated - Infertility Clinical Trials

Weight Adjusted Low Molecular Weight Heparin in Recurrent Implantation Failure: a Randomized Open Labeled Trial

Start date: July 2011
Phase: Phase 3
Study type: Interventional

Prospective randomized study of patients with infertility candidates to Assisted ReproductiveTechniques (ART), screened for all inclusion and exclusion criteria, submitted to ART cycle with or without low molecular weight heparin (LMWH) administration. Aims of the study are to evaluate, primarily, pregnancy rate/embryo transfer, secondarily take home babies/embryo transfer, implantation rate, and the role of thrombophilic factors

NCT ID: NCT02990949 Terminated - Infertility Clinical Trials

The Impact of the Timing of Trigger on IVF Success

Start date: November 2016
Phase: N/A
Study type: Interventional

The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.

NCT ID: NCT02940106 Terminated - Infertility Clinical Trials

Clinical Pregnancies After Cryopreservation of Donor Oocytes With an Open or Closed Device

Start date: October 2016
Phase: N/A
Study type: Interventional

This randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.

NCT ID: NCT02868528 Terminated - Infertility Clinical Trials

A Study of Preimplantation Genetic Screening With Next Generation Sequencing Technology on Advanced Age Women

Start date: September 23, 2016
Phase: N/A
Study type: Interventional

With the development of society, more and more aged pregnant women because of various reasons, their abnormality rate of egg chromosome was higher than that of young women, then the abnormality rate of embryo chromosome is higher too, so the pregnancy rate in aged women is lower, abortion rate is higher. In order to improve the pregnancy rate in aged women, cut down their abortion rate 、fetal birth with abnormal chromosome, and the risk of pregnancy termination after the prenatal diagnosis, reduce their pain of body and mind, the investigators will carry out this study. This is a prospective randomized controlled study of preimplantation genetic screening with Next generation sequencing technology. The embryos with more developmental potential and normal chromosomes should be selected. There is no related studies in Chinese. Most international research are limited to fluorescence in situ hybridization (FISH) technique, not on the embryo chromosome comprehensive screening. So there is no evidence of the effects of PGS on advanced age women. This study is to compare the outcomes between the advanced age women with two methods respectively. After blastocyst culture, blastocysts will be transferred in the control group. In the Preimplantation Genetic Screening (PGS) group, blastocyst embryo trophoblast biopsy will be performed and chromosome screening with Next generation sequencing(NGS) technology, at the same time, the blastocysts will be frozen, then the blastocysts with normal chromosome will be thawed and transferred. The investigators expect that, in PGS group live birth rate 、cancellation rate and pregnancy rate are higher than in control group; abortion rate is lower than that of the control group.