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NCT06297239 Clinical Trial

Argentine Registry of Lp(a)

Hypertension Clinical Trial

— GAELpa  

Official title:
Argentine Registry for the Study of Lipoprotein a

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06297239
Other study ID # UC001
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date February 1, 2024
Est. completion date February 1, 2026

Study information
Verified date February 2024
Source School of Medicine. National University of Cuyo
Contact Nicolás F Renna, MD PhD FESC
Phone +5492615714415
Email nicolasfede@gmail.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

The Argentine Registry on Lipoprotein(a) (LP(a)), orchestrated by the Argentine Group for LP(a) Study, stands as a pioneering and extensive prospective initiative. This registry systematically collects geolocation data, including patient postal codes, demographic information, and a multifaceted array of health parameters to unravel the intricate associations surrounding LP(a) levels. The dataset encompasses diverse patient characteristics, ranging from standard metrics like blood pressure, weight, and race to broader factors such as diabetes, smoking habits, menopausal status, and hypothyroidism. This holistic approach enables a nuanced exploration of the interplay between LP(a) levels and various risk factors, providing invaluable insights for both clinical and public health considerations. One distinctive feature of this registry lies in its focus on medication history, shedding light on the impact of routine pharmaceutical interventions on LP(a) profiles. Additionally, it delves into the intricate web of inflammatory diseases, recognizing their potential role in LP(a) modulation. Genetic predispositions are meticulously examined, with a specific emphasis on identifying homozygous and heterozygous variants associated with hypercholesterolemia. This genetic dimension adds a layer of complexity to the understanding of LP(a) dynamics, contributing significantly to the ongoing discourse on cardiovascular risk. The prospective nature of this registry allows for dynamic analyses, fostering a continuous exploration of emerging patterns and trends. By amalgamating geographical, clinical, and genetic data, the Argentine LP(a) Registry emerges as a comprehensive platform poised to unlock novel facets of LP(a) biology and its implications for cardiovascular health. As the dataset matures, it holds the promise of guiding personalized interventions and refining risk stratification strategies, thereby advancing the landscape of preventive cardiovascular care.

Recruitment information / eligibility
Status Recruiting
Enrollment 1000
Est. completion date February 1, 2026
Est. primary completion date February 1, 2026
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Adult patients with validated Lp(a) values - Exclusion Criteria: Associated pathologies that can increase the Lp(a) value in a non-specific manner -

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Argentina Universidad Nacional de Cuyo Mendoza

Sponsors (1)
Lead Sponsor Collaborator
School of Medicine. National University of Cuyo

Country where clinical trial is conducted

Argentina, 

Outcome
Type Measure Description Time frame Safety issue
Primary prevalence of high level of Lp(a) prevalence of high level of Lp(a) 2 years
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