Clinical Trials Logo
  1. Home
  2. Hypertension
  3. NCT03756103

Safety and Efficacy of SPH3127 on Treating Mild-moderate Essential Hypertension Patients

Hypertension,Essential Clinical Trial

Official title:
To Evaluate the Safety and Efficacy of SPH3127 on Treating Mild-moderate Essential Hypertension Patients: A Randomized, Double-Blinded, Dose-Exploration and Placebo-Controlled Study

Clinical Trial Summary

SPH3127 tablet is a of renin inhibitor. It is expected to be a new drug for essential hypertension. This is a phase IIa trial which designed to evaluate its efficacy and safety on treating mild-moderate essential hypertension patients.

Clinical Trial Description

This is a dose finding trial. Totally 120 mild-moderate essential hypertension patients will be enrolled. All the patients will be randomized (1:1:1:1) into four groups (SPH3127 50mg, SPH3127 100mg, SPH3127 200mg and placebo). The trial has three phases: the screening phase, the leading phase and the treating phase. The primary endpoints are the changes of DBP and SBP compared to the baseline after 8 weeks of treatment. All the adverse events are required to be collected for safety analyzing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03756103
Study type Interventional
Source Shanghai Pharmaceuticals Holding Co., Ltd
Contact
Status Completed
Phase Phase 2
Start date January 11, 2019
Completion date June 30, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT05086549 - An Observation Study to Evaluate the Renoprotective Effect of Fimasartan in Patients With DKD and Proteinuria
Recruiting NCT05086523 - Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study Phase 1/Phase 2
Active, not recruiting NCT03503773 - The TARGET BP OFF-MED Trial Phase 2
Not yet recruiting NCT04082091 - Screening, Early Referral and Lifestyle Tailored E_prescription for Cardiovascular Prevention
Recruiting NCT06019598 - Licorice and Home Blood Pressure, Additional Study N/A
Completed NCT04495231 - Sympathetic Activity and Cardiometabolic Complications
Completed NCT04119999 - A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling N/A
Recruiting NCT04505618 - Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease N/A
Recruiting NCT04863508 - Wearable Blood Pressure Devices to Identify Masked Uncontrolled Hypertension.
Completed NCT05185297 - Recreational Futsal for Controlled Hypertension N/A
Completed NCT03855605 - Diagnosis of Hypertension by Home Blood Pressure Monitoring
Completed NCT03901183 - Plant-based Nutrition for Patients With Cardiovascular Risk Factors N/A
Recruiting NCT03206814 - Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System N/A
Recruiting NCT06343246 - Functional Inspiratory Muscle Training in Patients Diagnosed With Hypertension N/A
Completed NCT06359873 - Left Atrial Enlargement: A Crucial Indicator for Identifying Atrial Fibrillation in Patients With Hypertension
Recruiting NCT04565548 - Hypertension Treatment Adherence Improving Trial N/A
Recruiting NCT06052748 - A Study to Evaluate the Efficacy and Safety of AD-223 Phase 3
Recruiting NCT04613193 - Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis N/A
Completed NCT03841383 - Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk
Recruiting NCT05413057 - An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ