Hypertension,Essential Clinical Trial
Official title:
Study to Investigate the Association Between Coronary Flow Reserve and BH4 Levels in Patients With High Cardiovascular Risk
To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .
Primary parameter :
relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in
patients with hypertension and concomitant cardiovascular risk factors.
Secondary parameter:
Levels of cGMP in platelets.
4. Study design
Three parallel groups of patients (n=15 per group):
- Group 1 with normal coronary flow reserve (CFR ≥2.5)
- Group 2 with reduced coronary flow reserve (CFR≤2.0)
o Group 3 control subjects (without a high risk profile according to ESC score chart
http://www.heartscore.org. ) matched for age (between 40 and 80 years of age)
- and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes)
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