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Clinical Trial Summary

To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .


Clinical Trial Description

Primary parameter :

relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with hypertension and concomitant cardiovascular risk factors.

Secondary parameter:

Levels of cGMP in platelets.

4. Study design

Three parallel groups of patients (n=15 per group):

- Group 1 with normal coronary flow reserve (CFR ≥2.5)

- Group 2 with reduced coronary flow reserve (CFR≤2.0)

o Group 3 control subjects (without a high risk profile according to ESC score chart http://www.heartscore.org. ) matched for age (between 40 and 80 years of age)

- and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes) ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03841383
Study type Observational
Source IRCCS San Raffaele
Contact
Status Completed
Phase
Start date June 6, 2017
Completion date July 10, 2019

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