Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System

Hypertension,Essential Clinical Trial

— CHARGE-APP  

Official title:

Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03206814
• Other study ID #: 09A721
• Status: Recruiting
• Phase: N/A
• Start date: May 11, 2021
• Est. completion date: December 2024

Study information

• Verified date: August 2023
• Source: Istituto Auxologico Italiano
• Contact: Gianfranco Parati, MD
• Phone: +390261911
• Email: gianfranco.parati[@]unimib.it
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The CHARGE-APP project will investigate whether an innovative management strategy of hypertension based on the combination of usual care visits and ESH CARE App compared to standard care, is associated with differences in outcome, including control rate of office, home and ambulatory BP, cardiovascular and renal intermediate end points at one year, and changes in a number of blood pressure-related variables throughout the study.

Description:

CHARGE-APP is a proof-of-concept one-year prospective, randomized, open-label, blinded endpoint study (PROBE) including 2 groups of patients randomized to different treatment strategies:

1. a new management strategy, named POST (i.e. "Patient Optimal Strategy for Treatment"), consisting in providing the patients with a system to communicate home blood pressure measurements to a referral centre, and the referral centre with an online platform to organize and easily interpret the information sent by patients and to monitor the patients' status;

2. usual care, consisting in regular visits at the referral centre.

Patients will be enrolled over 3 months and will be randomly allocated to one of the study groups. Follow-up phase will last 12 months after randomization and will focus on changes in ambulatory systolic BP (primary endpoint), in diastolic ambulatory BP, in office SBP and DBP, in Home SBP and DBP, in left ventricular mass index (LVMI) and urinary albumin excretion (UAE), all secondary end-points.

All patients will perform visits at baseline, three, six and twelve months. Physical examination, history of the patient and clinical blood pressure values will be obtained at every visit.

Echocardiogram, ECG, urine samples (UAE, urinary albumin/creatinine and 24-h ambulatory blood pressure monitoring (ABPM) will be performed at baseline, three months, six months and study end.

Blood samples (full blood count, creatinine, Na+, K+, fasting glucose, HbA1c, uric acid, lipids) will be performed at baseline; another blood sample will be collected at twelve months for measurement of serum creatinine (and renal function). UAE will be measured at baseline and study end, on morning urine samples.

Patients randomized to POST-strategy will measure Home BP two days a week (two measurements in the morning and two measurements in the evening) and communicate these values with the ESH CARE app; furthermore, before each visit they will measure their Home BP for 7 consecutive days (two measurements in the morning and two measurements in the evening), according to current guidelines on hypertension.

Patients randomized to usual care will also measure Home BP for 7 consecutive days at baseline and at study end, to provide a comparison. Operators (i.e. investigators dedicated to the follow-up of POST-strategy) will check these data organized by the POST system at least every 15 days, and adjust pharmacological therapy, if needed.

In patients randomized to usual care, therapy will be adjusted only at follow-up visits (i.e. at three and six months).

Pharmacological therapy will be increased or decreased according to blood pressure values; investigators may follow a therapy algorithm based on ESH/ESC guidelines, but are free to individualize it.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 480
• Est. completion date: December 2024
• Est. primary completion date: December 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Male and female subjects;

• Age 18-80 years;

• Either the patient or another person close to him/her should possess a smartphone compatible with the ESH CARE app and be capable of using it;

• Uncontrolled (untreated or treated) hypertension, defined as office BP =140/90 mmHg, and Ambulatory 24h ABP =130/80 mmHg

Exclusion Criteria:

• eGFR <45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009);

• Severe uncontrolled hypertension (i.e. BP =200/120 mmHg despite treatment);

• Known secondary hypertension;

• Orthostatic hypotension (SBP fall > 20 mmHg on standing);

• Unstable clinical conditions or severe disease with short life expectation;

• Known atrial fibrillation;

• Hepatic disease as determined by either AST or ALT values > 2 times the upper limit of normal;

• History of gastrointestinal surgery or disorders which could interfere with drug absorption

• History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years;

• History of clinically significant autoimmune disorders such as systemic lupus erythematosus;

• History of drug or alcohol abuse within the last 5 years;

• History of non-compliance to medical regimens and/or patients who are considered potentially unreliable;

• Dementia (clinical diagnosis);

• Inability or unwillingness to give free informed consent;

• Inability to use even simple communication technologies;

• Pregnancy or planned pregnancy during study period

Related Conditions & MeSH terms

• Essential Hypertension
• Hypertension
• Hypertension, Uncontrolled
• Hypertension,Essential

Intervention

Other:
• Usual care
Antihypertensive therapy is adjusted every 3 months on the basis of office blood pressure values.
• POST-strategy
Antihypertensive therapy is adjusted every 15 days on the basis of home blood pressure values.

Locations

Country	Name	City	State
Argentina	Spanish Hospital of Mendoza	Mendoza
China	Shanghai Institute of Hypertension	Shanghai	Huangpu

Sponsors (1)

Lead Sponsor	Collaborator
Istituto Auxologico Italiano

Countries where clinical trial is conducted

Argentina,  China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Ambulatory Systolic Blood Pressure	Change in ambulatory 24h systolic blood pressure	12 months
Secondary	Ambulatory Diastolic Blood Pressure	Change in ambulatory 24h diastolic blood pressure	12 months
Secondary	Difference between Office Blood Pressure and Home Blood Pressure	Differences between office blood pressure and home blood pressure (both systolic and diastolic)	12 months
Secondary	Left ventricular mass index	Change in left ventricular mass index by ecocradiographic evaluation	12 months
Secondary	Left ventricular hypertrophy	Change in ECG indices of left ventricular hypertrophy	12 months
Secondary	Urinary albumin to creatinine ratio	Change in urinary albumin to creatinine ratio	12 months
Secondary	Estimated glomerular filtration rate	Change in estimated glomerular filtration rate	12 months
Secondary	Normalization rate of blood pressure	Normalization rate of BP by all the measuring devices: office BP, HOME BP and ABPM	12 months
Secondary	ABPM variables	Change in a number of variables derived from ABPM (day-time SBP/DBP, Night-time SBP/DBP, nocturnal dipping of SBP/DBP, morning surge of SBP/DBP, BPV (daytime and night-time SBP/SBP SD, CV; 24h SBP/DBP ARV, 24h SBP/DBP wSD, AASI)	12 months
Secondary	Prescribed antihypertensive drugs	Number of prescribed antihypertensive drugs	12 months