Optimization of Blood Pressure Management After Acute Ischemic Stroke and Its Prognostic Significance

Hypertension Clinical Trial

Official title: Optimization of Blood Pressure Management After Acute Ischemic Stroke and Its Prognostic Significance: Prospective, Randomized, Open, Blinded Outcome Evaluation, and Feasibility Trial

Status Completed

Clinical Trial Summary

BOSS-Trial I is a phase 2 clinical trial with the following objectives;

1. to prove the feasibility of a Bluetooth-equipped sphygmomanometer system in real-world clinical practice and wireless connection to the main server;

2. to prove the feasibility of the BP management strategy, including the pre-specified BP range, BP management algorithm, and behavioral; and

3. to gather information for the phase 3 trial including BP variability indices and their potentials as a treatment guidance.

Clinical Trial Description

• Elevated blood pressure is an established risk factor for recurrent stroke and vascular events in ischemic stroke survivors, but

• Current guideline (JNC VIII) has omitted or only partially covered a number of practical and important issues as follow;

• When and how we measure blood pressure?

• Is it justifiable to apply the same blood pressure threshold for office BP and home BP?

• Should stroke survivors be treated by the same BP goal for non-stroke subjects?

• Is it justifiable to apply the universal BP threshold for different mechanisms of ischemic stroke?

• Is it really about only blood pressure or might it really be "beyond blood pressure?"

• Lifestyle modification should accompany all the pharmacological intervention but is usually in adequate to initiate behavioral changes.

• Frequent BP measurement at home will provide more detailed and reliable information than occasional office BP's. ;

Related Conditions & MeSH terms

• Cerebral Infarction
• Hypertension
• Ischemia
• Ischemic Stroke
• Stroke

• NCT number: NCT03024476
• Study type: Interventional
• Source: Seoul National University Bundang Hospital
• Status: Completed
• Phase: Phase 2
• Start date: September 1, 2016
• Completion date: December 7, 2017