Hypertension Clinical Trial
To investigate psychosocial and dietary influences on blood pressure in Blacks.
BACKGROUND:
Socioeconomic status as measured by education, income and/or occupation is generally
inversely associated with hypertension-risk. John Henryism research is designed to test the
psychosocial stress hypothesis that low SES Blacks who are strongly predisposed to overcome
difficult life circumstances through effortful active coping might have higher blood
pressure than their more relaxed neighbors and that John Henryism and anger suppression are
positively correlated in Blacks.
The first two years of the project analyzed data collected on 1,548 Black and white men and
women in Edgecombe County, North Carolina. The Edgecombe County data were collected in 1983
to provide data for a representative sample of households to be used in evaluating the
effectiveness of a community high blood pressure control program. Approximately 50 percent
of the sample was Black and 56 percent women. In the first year, measurements were made in
all four race-sex groups of the effect-modifying role of John Henryism on education and on
alternative measures of SES. In the second year, analyses were conducted on the degree to
which job security, marriage, and socioeconomic mobility predict blood pressure in each
race-sex group.
DESIGN NARRATIVE:
A survey was conducted of 2,017 Black men and women in Pitt County, North Carolina. Study
variables included age, sex, marital status, socioeconomic status (SES), John Henryism
(behavioral predisposition to cope actively with psychosocial environmental stressors),
social support, anger-coping style, social desirability, dietary variables including sodium,
potassium, calcium and alcohol, blood pressure, height, weight, and pregnancy. In the
cross-sectional study, blood pressure was the continuous outcome as measured by linear
regression. Three years after baseline all normotensive persons were re-examined in order to
measure changes in blood pressure from baseline after exposure to selected psychosocial and
dietary factors. The study provided an estimate of the degree to which John Henryism, social
support, anger-coping and dietary factors modify the association between SES and blood
pressure in Blacks.
The study was renewed in 1993 to re-examine the 1,429 respondents (571 men, 912 women) with
untreated, mean diastolic blood pressure < 95 mmHg at baseline, and again at follow-up, on
changes in blood pressure during the intervening four to five years (1988-1992/93). The
social variables included socioeconomic status, John Henryism, stress, and social support;
the dietary variables included alcohol, sodium, potassium, and calcium; and the
anthropometric variables included body mass index (BMI) and waist/hip ratio (WHR). With an
emphasis on SES, physical activity, dietary habits, and cigarette smoking, the predictors of
weight gain, and changes in patterning of body fat were also examined. Multiple linear
regression was the primary analytic tool used to study these longitudinal relationships. In
cross-sectional analyses which controlled for physical activity and other important
variables, the roles of insulin resistance in mediating associations between obesity and
blood pressure, and stress and blood pressure, were also examined.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
| Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
| Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
| Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
| Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
| Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
| Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
| Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
| Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
| Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
| Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |