Hyperglycemia Clinical Trial
— BRAIN-GLULACOfficial title:
Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury in the Intensive Care Unit - a Prospective, Observational Cohort Study
This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
Status | Recruiting |
Enrollment | 875 |
Est. completion date | October 30, 2024 |
Est. primary completion date | April 30, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age = 18 years - Admission to the neurointensive care unit at Rigshospitalet - Diagnosis of acute brain injury categorised as TBI, SAH, ICH, ischaemic stroke, or other conditions Exclusion Criteria: - Brain death before inclusion - Closest relatives do not understand written and spoken Danish or English |
Country | Name | City | State |
---|---|---|---|
Denmark | Department of Neuroanesthesiology and Neurointensive Care, Rigshospitalet | Copenhagen |
Lead Sponsor | Collaborator |
---|---|
Rigshospitalet, Denmark |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Functional outcome at 6 months as evaluated by the modified Rankin Scale. | Modified Rankin Scale ranges from 0-6, where 0 is the best and 6 is the worst outcome. | 6 months after admission. | |
Secondary | All-cause mortality at 6 months (dichotomous). | 6 months after admission. | ||
Secondary | Length of stay in the neuro-ICU (continuous). | Day of discharge, typically 1-30 days after admission. |
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