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Hyperlactatemia clinical trials

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NCT ID: NCT06292910 Completed - Clinical trials for Congenital Heart Disease

Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac Surgery

VACO2
Start date: August 8, 2021
Phase:
Study type: Observational

The goal of this clinical trial is to compare the capability of 3 different bedside surrogates in children who underwent cardiac surgery and were admitted in intensive care unit. These test are lactate, oxygen saturation from central venous and the carbon dioxide gap between central venous and arterial. The main questions is which one is the best prognostication for post operation poor outcomes Participants will be taken routine blood test for post cardiac care (at ICU arrival, 6, 12, and 24 hour post operation) and follow the their outcomes. There is no any intervention or drug in this research

NCT ID: NCT06222021 Not yet recruiting - Clinical trials for Postoperative Complications

Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors

NETTUNO
Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to identify those situations in which the increase of lactate levels is not clinically relevant since it is associated with altered genetic polymorphism of the genes involved in the membrane proteins acting as carriers for lactate (mainly monocarboxylate transporters, MCTs) patients undergoing major abdominal surgery. The main questions it aims to answer are: 1. Is there a relationship between the lactate levels in the immediate post-operative period and the presence of some lactate receptor polymorphisms? 2. Can hyperlactacidemia related to lactate receptor polymorphisms affect length of stay in the recovery room and/or in intensive care unit, postoperative hospital stay, postoperative complications? - Which are the risk factors for hyperlactacidemia in the immediate post-operative period in addition to the presence of lactate receptors polymorphisms? Participants will undergo pre-operative genomic assay testing.

NCT ID: NCT05953142 Not yet recruiting - Sepsis Clinical Trials

Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.

DEEP
Start date: February 1, 2024
Phase: Phase 2
Study type: Interventional

This phase 2 study aim to investigate the effect of dobutamine in patients with sepsis/ septic shock after fluid resuscitation and with hypoperfusion (lactate and central venous oxygen saturation or prolonged capillary refill time) on renal function as compared with usual care.

NCT ID: NCT05816291 Completed - Clinical trials for Lactate Blood Increase

Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses

VP
Start date: March 30, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the health and performance outcomes associated with supplementation of Veillonella atypica.

NCT ID: NCT05649358 Completed - Hyperlactatemia Clinical Trials

Pilot Testing a Novel Non-invasive Lactate Sensor

Start date: December 5, 2022
Phase: N/A
Study type: Interventional

To test the efficacy and accuracy of a novel non-invasive lactate sensor in humans undergoing strenuous leg exercise.

NCT ID: NCT05611398 Completed - Clinical trials for Lactate Blood Increase

Lactate Monitoring in Traumatic Long Bone Fractures Requiring Emergent Surgical Intervention

Start date: January 1, 2021
Phase:
Study type: Observational

Serum lactate has been utilized as a standard in guiding management of orthopedic injuries. Elevated preoperative lactate has been associated with a higher likelihood of postoperative complications. However, lactate's role in guiding operative timing in non-critical long-bone fractures has not been previously explored. This study investigates lactate's role in guiding surgical timing and predicting complications secondary to delayed definitive correction in non-critical long-bone fractures with Injury Severity Score <16.

NCT ID: NCT05505396 Recruiting - Hyperglycemia Clinical Trials

Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury

BRAIN-GLULAC
Start date: October 24, 2022
Phase:
Study type: Observational

This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.

NCT ID: NCT05295836 Completed - Clinical trials for Antioxidative Stress

Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes

Start date: February 10, 2022
Phase: N/A
Study type: Interventional

This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in international athletes in hot conditions. The investigators hypothesized that acute glycerol ingestion can prevent performance loss (power generated at submaximal intensity) in hot conditions. To justify this hypothesis, the investigators will measure the aforementioned markers, which could establish a cause-effect relationship between acute glycerol intake and decreased performance loss in hot conditions.

NCT ID: NCT05145049 Completed - Brain Tumor Clinical Trials

The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies

Start date: November 1, 2021
Phase:
Study type: Observational [Patient Registry]

The investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method applied (inhalation anesthesia or total ıntravenous anesthesia) affects lactate level.

NCT ID: NCT05108467 Recruiting - Clinical trials for Lactate Blood Increase

Saving Lives by Early Detection and Treatment of Sepsis and Septic Shock by Point of Care Lactate Test in Adults

POCLactate
Start date: October 21, 2021
Phase:
Study type: Observational

Burden: The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20% of all global deaths. Recent chart analysis from Dhaka Hospital, icddrb recorded 350 adults with severe sepsis admitted over four years. Among them, 69% of patients progressed to septic shock. Knowledge gap: Clinical features of shock due to sepsis and shock due to severe dehydration are very intertwining and often predicament for critical care physicians. If not recognized early and managed promptly, it can lead to septic shock, multiple organ failure, and eventually death. Serum lactate may play a role as the point of care test in differentiating shock due to severe sepsis from shock due to severe dehydration. Relevance: Being the largest diarrhoeal disease hospital, the Dhaka Hospital of icddr,b is ideal for researching shock with diarrheal diseases. Even though the onset of sepsis can be acute and poses a short-term mortality burden, it can also cause significant long-term morbidity, requiring treatment and support. Thus, addressing sepsis and severe sepsis by early detection and prompt management should be a comprehensive way to reduce the burden in our community.