HIV Infections Clinical Trial
Official title:
A Study of Innate Immunity in HIV Positive Patients Co-infected With Hepatitis C or Hepatitis B
Data from this study will provide the first information how the innate immune system may be altered in HIV-HCV and HIV-HBV co-infected individuals, and describe Toll-like receptor changes with HIV co-infection therapy.
It has been demonstrated that Toll-like receptors (TLR) are involved in viral hepatitis -
hepatitis B (HBV), hepatitis C (HCV) - and HIV in the setting of mono-infection. However the
role of innate immunity in the pathogenesis of HIV-hepatitis co-infection in both natural
and therapy-associated viral clearance remains unclear. The data from this study may reveal
patterns which could predict how and when patients spontaneously, and with therapy, resolve
HBV or HCV in the setting of co-infection.
The aim of the study is to evaluate the activity of innate immunity in different subsets of
HIV-infected populations co-infected with chronic hepatitis B and/or C. Our hypothesis is
that innate immunity is altered in HIV and hepatitis co-infection and that this differs from
both hepatitis and HIV mono-infection.
The study is a cross-sectional and longitudinal pilot study of individuals infected with HIV
and either HBV or HCV.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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