HIV Infections Clinical Trial
Official title:
Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) co-Infection and Liver Disease
Human immunodeficiency virus/Hepatitis B virus (HIV/HBV) co-infections are frequently
observed due to shared routes of transmission, with reported figures indicating 6-9% of
HIV-infected individuals in developed countries are chronically infected with HBV. HIV
infection impacts on the natural progression of HBV infection, increasing levels of HBV
replication and the risk of liver-associated mortality. Liver diseases associated with HBV
are affected by the antiviral drugs used for HIV infection (toxic side effects), the current
immune function in the patient, by improvements in the immune system brought about by
control of the HIV infection, and by the development of resistance to the antiviral agents
used for both the hepatitis B and the HIV infection. Co-infection with HBV increases the
risk for hepatotoxicity in those individuals receiving highly active antiretroviral therapy
(HAART) for their HIV infection.
This study will recruit patients who are co-infected with HIV and HBV, and are currently
taking or who are about to commence HAART. The study cohort will include HIV-HBV co-infected
individuals from the Alfred Hospital, the Royal Melbourne Hospital and high case load GP
clinics who are referred to the Alfred Hospital.
The aim of the study is to investigate chronic hepatitis B and its impact on the progression
of liver disease in HIV-infected persons receiving HAART.
This will be achieved by 6 monthly assessment with medical history, physical examination,
bloods for markers of liver disease and hepatitis B activity and completion of
questionnaires to measure adherence and alcohol use.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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