HIV Infections Clinical Trial
The purpose of this study is to identify differences in TB specific immune responses among immunosuppressed patients latently infected with TB and patients with active TB.
Immunosuppressed patients latently infected with TB are at higher risk of developing active
TB than patients with normal immune functions. Especially two patient categories are at
risk: HIV positives and patients receiving TNF-a blocking medication. Existing methods of
diagnosis and surveillance of latent TB infection can not identify who will develop active
TB and who can control the infection. There is a need for better understanding of TB
specific immune functions,as we believe deficient TB specific immune reactions is a key in
reactivation of latent TB infection.
In this study we follow groups of latent TB infected patients with either rheumatoid
arthritis or HIV. We follow the patients during treatment with TNF-a blocking medication,
HAART treatment or prophylactic TB medication. Results are correlated to patients with
active TB, latent TB and healthy controls.
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Observational Model: Defined Population, Time Perspective: Longitudinal
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