HIV Infections Clinical Trial
Official title:
Virological and Immunological Studies of HIV-1 Infection in Newly Infected Individuals in Southern Africa
NCT number | NCT00006298 |
Other study ID # | HIVNET 028 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | September 26, 2000 |
Last updated | September 24, 2008 |
The main goal of this study is to find out how the immune system responds to a specific type
of HIV infection, known as C HIV-1, in order to develop a vaccine against this type of
infection. The study involves Southern African populations.
The HIV-1 virus changes rapidly and many different subtypes have been found. In South
Africa, limited data have suggested Subtype C HIV-1 is the most common. This study strives
to verify the most common subtype and also look at genetic differences and immune responses
among newly infected individuals. Results will aid in the development of vaccines specific
for certain geographical areas.
Status | Completed |
Enrollment | 125 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria Participants may be eligible for this study if they: - Are first HIV-negative and later test HIV-positive; or are HIV-positive and have evidence of being HIV-negative within the 8 months prior to first testing HIV-positive; or are HIV-positive with one test and HIV-negative with another test. Exclusion Criteria Participants will not be eligible for this study if they: - Have a mental disorder that interferes with agreeing to do the study or with participating in the study. - Are receiving anti-HIV treatment for more than 4 weeks. - Have tuberculosis. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | Missie Allen | Research Triangle Park | North Carolina |
Lead Sponsor | Collaborator |
---|---|
National Institute of Allergy and Infectious Diseases (NIAID) |
United States,
Masemola A, Mashishi T, Khoury G, Mohube P, Mokgotho P, Vardas E, Colvin M, Zijenah L, Katzenstein D, Musonda R, Allen S, Kumwenda N, Taha T, Gray G, McIntyre J, Karim SA, Sheppard HW, Gray CM; HIVNET 028 Study Team. Hierarchical targeting of subtype C hu — View Citation
Masemola AM, Mashishi TN, Khoury G, Bredell H, Paximadis M, Mathebula T, Barkhan D, Puren A, Vardas E, Colvin M, Zijenah L, Katzenstein D, Musonda R, Allen S, Kumwenda N, Taha T, Gray G, McIntyre J, Karim SA, Sheppard HW, Gray CM; HIVNET 028 Study Team. N — View Citation
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