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Analysis of Genetic Factors Which May Influence the Course of HIV Infection

HIV Infection Clinical Trial

Official title:
Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Clinical Trial Summary

Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.

Clinical Trial Description

Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00159068
Study type Observational
Source Hadassah Medical Organization
Contact
Status Completed
Phase N/A
Start date February 2004
Completion date April 2011
View Details
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