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NCT00159068 Clinical Trial

Analysis of Genetic Factors Which May Influence the Course of HIV Infection

HIV Infection Clinical Trial

Official title:
Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00159068
Other study ID # 391200-HMO-CTIL
Secondary ID
Status Completed
Phase N/A
First received September 9, 2005
Last updated August 9, 2017
Start date February 2004
Est. completion date April 2011

Study information
Verified date August 2017
Source Hadassah Medical Organization
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.

Description:

Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date April 2011
Est. primary completion date April 2011
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- diagnosis of HIV

Exclusion Criteria:

- under 18 years of age

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Hadassah Medical Organization Jerusalem

Sponsors (1)
Lead Sponsor Collaborator
Deborah Rund

Country where clinical trial is conducted

Israel, 

References & Publications (1)

Tang J, Kaslow RA. The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. AIDS. 2003;17 Suppl 4:S51-60. Review. — View Citation

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