Akershus Cardiac Examination (ACE) 1950 Study

Heart Failure Clinical Trial

— ACE1950  

Official title:

Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01555411
• Other study ID #: 2011/1475 C
• Secondary ID: AFIA (initial st
• Status: Active, not recruiting
• Start date: September 2012
• Est. completion date: December 1, 2050

Study information

• Verified date: December 2022
• Source: Vestre Viken Hospital Trust
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Description:

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway. Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015. Follow-up and sub-studies are ongoing. Current status: As per May 2018, follow-up and sub-studies are ongoing.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 3706
• Est. completion date: December 1, 2050
• Est. primary completion date: December 1, 2050
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 62 Years to 65 Years

Eligibility

Inclusion Criteria:

• Resident in Akershus County (as per October 2011, prior to study invitation)
• Born in the year of 1950
• Ability to consent to participation

Related Conditions & MeSH terms

• Atrial Fibrillation
• Cardiovascular Diseases
• Cerebrovascular Disorders
• Cognitive Dysfunction
• Heart Failure
• Mild Cognitive Impairment

Locations

Country	Name	City	State
Norway	Akershus University Hospital	Lørenskog	Akershus
Norway	Vestre Viken HT, Baerum Hospital, Department of Medical Research	Sandvika	Akershus

Sponsors (2)

Lead Sponsor	Collaborator
Vestre Viken Hospital Trust	University Hospital, Akershus

Country where clinical trial is conducted

Norway, 

References & Publications (9)

Aagaard EN, Kvisvik B, Pervez MO, Lyngbakken MN, Berge T, Enger S, Orstad EB, Smith P, Omland T, Tveit A, Rosjo H, Steine K. Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. Eur Heart J — View Citation

Berge T, Brynildsen J, Larssen HKN, Onarheim S, Jenssen GR, Ihle-Hansen H, Christophersen IE, Myrstad M, Rosjo H, Smith P, Tveit A. Systematic screening for atrial fibrillation in a 65-year-old population with risk factors for stroke: data from the Akersh — View Citation

Berge T, Lyngbakken MN, Ihle-Hansen H, Brynildsen J, Pervez MO, Aagaard EN, Vigen T, Kvisvik B, Christophersen IE, Steine K, Omland T, Smith P, Rosjo H, Tveit A. Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old genera — View Citation

Berge T, Vigen T, Pervez MO, Ihle-Hansen H, Lyngbakken MN, Omland T, Smith P, Steine K, Rosjo H, Tveit A; ACE 1950 Study Group. Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design. Scand Cardiovasc J. 2015;49(6):308-15. doi: 10.3109/14017431.2015.1086813. Epub 2015 Sep 12. — View Citation

Chandra A, Rosjo H, Eide IA, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Lyngbakken MN, Berge T, Schmidt EB, Omland T, Tveit A, Svensson M. Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. Eur — View Citation

Ihle-Hansen H, Vigen T, Berge T, Einvik G, Aarsland D, Ronning OM, Thommessen B, Rosjo H, Tveit A, Ihle-Hansen H. Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examinatio — View Citation

Ihle-Hansen H, Vigen T, Berge T, Hagberg G, Engedal K, Ronning OM, Thommessen B, Lyngbakken MN, Nygard S, Rosjo H, Tveit A, Ihle-Hansen H. Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Card — View Citation

Ihle-Hansen H, Vigen T, Ihle-Hansen H, Ronning OM, Berge T, Thommessen B, Lyngbakken MN, Orstad EB, Enger S, Nygard S, Rosjo H, Tveit A. Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus C — View Citation

Vigen T, Ihle-Hansen H, Lyngbakken MN, Berge T, Thommessen B, Ihle-Hansen H, Orstad EB, Enger S, Ariansen I, Rosjo H, Tveit A, Ronning OM. Blood pressure at age 40 predicts carotid atherosclerosis two decades later: data from the Akershus Cardiac Examinat — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort		Within 35 years
Other	Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort		Maximum 35 years
Primary	Outcomes related to CVD and CV-associated conditions		Maximum 35 years
Secondary	Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc.		Maximum 35 years
Secondary	Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc.		Maximum 35 years
Secondary	Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc.		Maximum 35 years

External Links

•   Study website