Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness. The main questions it aims to answer are: - Does the antiseizure medication reduce the functional connectivity of seizure networks, as identified by resting state functional MRI (rs-fMRI), within this specific target population? - What is the prevalence of seizure networks in patients from the target population, both with EEG suggestive and not suggestive of epileptogenic activity? Participants will have a rs-fMRI and those with seizure networks will receive treatment with two antiseizure medications and a post-treatment rs-fMRI. Researchers will compare the pretreatment and post-treatment rs-fMRIs to see if there are changes in the participant's functional connectivity including seizure networks and typical resting state networks.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06081283
Study type	Interventional
Source	University of North Carolina, Chapel Hill
Contact	Emilio G. Cediel, MD
Phone	9847582948
Email	egcediel@email.unc.edu
Status	Recruiting
Phase	Phase 4
Start date	November 20, 2023
Completion date	February 2025

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