Healthy Clinical Trial
Official title:
Investigations in Discourse Processes
This research trial will study discourse processing-that is, how the brain processes the
meaning of language. It will examine, for example, how words and sentences are interpreted
in cases where more than one meaning is possible. The study will include two parts:
1. An investigation of the role of the prefrontal cortex of the brain in discourse
processing will compare test performance of patients with prefrontal cortex damage with
that of healthy age-matched normal volunteers.
2. An investigation of the role of aging in discourse processing will compare test
performance of young healthy subjects (18 to 40 years old) with older healthy subjects
(41 to 80 years old).
All study candidates-both normal volunteers and patients with brain damage-must be at least
18 years old, speak English as their native language, have a high school degree or
equivalent (GED), read on a minimum fourth grade level and be right-handed.
Study candidates who have central nervous system disease, dysfunction or trauma will have a
routine history and neurological examination. They will also undergo neuropsychological
testing if they have not already done so. Patients with neurological damage who have not had
a magnetic resonance imaging (MRI) scan within six months or a year will be asked to undergo
this procedure.
Study participants will take verbal or written tests; sit in front of a computer screen and
press computer keys in response to what they are shown; answer questions from an examiner,
which may be tape-recorded; and fill out questionnaires. There will be rest breaks between
tasks. The studies will be spread over three to four days, with sessions lasting from 30
minutes to three hours.
Status | Completed |
Enrollment | 500 |
Est. completion date | March 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: All subjects will be between the ages of 18-80, fluent English speakers, premorbidly right handed, and literate for stimulus sentences that are written at a minimum of a 4th grade reading level. In addition, all subjects will have a minimum high school or GED education, sufficient hearing acuity (aided or unaided) and auditory comprehension to follow task instructions, adequate visual acuity (aided or unaided) to read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys in response to stimuli. Healthy subjects will have no history of mental, cognitive or other neurological deficits, adequate hearing and visual acuity (corrected or uncorrected) to follow task instructions and read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys to response stimuli. As with BD subjects, healthy subjects will be right handed, native English speakers, and literate for stimulus sentences. The Mini-Mental State Examination (Folstein et al., 1975) will be administered as a cognitive screen for healthy subjects, using a cut-off score of 27 (of total 30) for inclusion on the protocol. For prefrontal BD subjects, only adult patients with focal damage confined to the prefrontal lateral or orbitomedial areas of either or both hemispheres will be included in the study. Cortical damage will be determined on the bases of neurological and neuropsychological examinations and confirmed by MRI or CT studies. All patients with stroke and penetrating head injury will be tested at least 3 months post-onset of neurological damage to ensure a stable medical condition. All patients with resected brain tumor will have completed radiation therapy and regimen of steroid medication. Dates and course of radiation therapy will be documented. It should be emphasized that the BD subjects to be included on this protocol will have selective deficits (on the basis of neuropsychological test findings and screening to determine candidacy) and will be able to understand the purpose of our studies, the instructions for our tasks, and response demands. Patients who cannot understand the purpose of our studies, or the instructions or response demands of the tasks would not meet entry criteria. Only those subjects who pass the screening will be accepted on the protocol. Exclusion Criteria: Healthy subjects will have no history of mental, cognitive or other neurological deficits. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | Warren G. Magnuson Clinical Center (CC) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institutes of Health Clinical Center (CC) |
United States,
Faust ME, Gernsbacher MA. Cerebral mechanisms for suppression of inappropriate information during sentence comprehension. Brain Lang. 1996 May;53(2):234-59. Erratum in: Brain Lang 1997 Jan;56(1):159. — View Citation
Mani K, Johnson-Laird PN. The mental representation of spatial descriptions. Mem Cognit. 1982 Mar;10(2):181-7. — View Citation
Rehak A, Kaplan JA, Weylman ST, Kelly B, Brownell HH, Gardner H. Story processing in right-hemisphere brain-damaged patients. Brain Lang. 1992 Apr;42(3):320-36. — View Citation
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