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Gastric Cancer clinical trials

View clinical trials related to Gastric Cancer.

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NCT ID: NCT04798781 Active, not recruiting - Clinical trials for Hepatocellular Carcinoma

Safety and Efficacy of Telatinib in Combination With Keytruda in Subjects With Advanced Stomach and Gastroesophageal Junction Cancers or Hepatocellular Carcinoma

Start date: July 28, 2021
Phase: Phase 2
Study type: Interventional

This is a phase II, single arm, open-label study of two parallel cohorts (advanced stomach and gastroesophageal junction cancer and hepatocellular carcinoma), evaluating the effects of telatinib in combination with Keytruda on progression-free survival.

NCT ID: NCT04772989 Active, not recruiting - Multiple Myeloma Clinical Trials

A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

ARC-12
Start date: March 19, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1/1b, multicenter, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of AB308 in combination with zimberelimab (AB122) in participants with advanced malignancies.

NCT ID: NCT04661150 Active, not recruiting - Gastric Cancer Clinical Trials

A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction

Start date: March 12, 2021
Phase: Phase 2
Study type: Interventional

This is a phase II, multicenter, randomized, open-label study designed to evaluate the efficacy and safety of perioperative trastuzumab+XELOX with / without atezolizumab in participants eligible for surgery with locally advanced HER2-positive gastric cancer or adenocarcinoma of GEJ.

NCT ID: NCT04611997 Active, not recruiting - Gastric Cancer Clinical Trials

IGG Using in Laparoscopic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy

Start date: November 16, 2020
Phase: Phase 3
Study type: Interventional

Patients with locally advanced gastric adenocarcinoma (cT2-4a N-/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph node dissection for gastric cancer after neoadjuvant chemotherapy by comparing injection ICG group and non-injection ICG group

NCT ID: NCT04593615 Active, not recruiting - Surgery Clinical Trials

Indocyanine Green Tracer Using in Laparoscopic Radical Gastrectomy for Locally Advanced Gastric Cancer

CLASS-11
Start date: November 10, 2020
Phase: N/A
Study type: Interventional

Patients with locally advanced gastric adenocarcinoma (CT2-4a N0/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph node dissection for gastric cancer by comparing injection ICG group and non-injection ICG group.

NCT ID: NCT04579757 Active, not recruiting - Colorectal Cancer Clinical Trials

Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors

Start date: March 5, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This open-label, phase Ib/II study of surufatinib in combination with tislelizumab will evaluate the safety, tolerability, PK and efficacy in patients with advanced solid tumors. The study consists of 2 parts - dose finding (Part 1) and dose expansion (Part 2).

NCT ID: NCT04513223 Active, not recruiting - Colorectal Cancer Clinical Trials

A Phase 1 Study of SHR-A1811 in Patients With Selected HER2 Expressing Tumors

Start date: March 30, 2021
Phase: Phase 1
Study type: Interventional

This is a single arm, open-label, dose escalation, PK expansion and efficacy expansion study of phase I. The purpose of this study is to assess the tolerability, safety, pharmacokinetics and immunogenicity of SHR-A1811 and preliminary anti-tumor efficacy in HER2-expressing advanced gastric or gastroesophageal junction adenocarcinoma and colorectal cancer.

NCT ID: NCT04454476 Active, not recruiting - Gastric Cancer Clinical Trials

Reversal of Preneoplastic Metaplasia in the Stomach With MEK Inhibitor

Start date: November 9, 2022
Phase: Phase 1
Study type: Interventional

This is a study of the safety and effectiveness of Trametinib treatment in patients who have received successful endoscopic submucosal resection of a Stage I gastric cancer.

NCT ID: NCT04404595 Active, not recruiting - Pancreatic Cancer Clinical Trials

Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers

Start date: October 23, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

A Phase 1b/2, open label, multi-center, clinical study of Chimeric Antigen Receptor T Cells (CAR-T) targeting claudin18.2 in patients with advanced gastric, pancreatic or other specified digestive system cancers

NCT ID: NCT04365946 Active, not recruiting - Gastric Cancer Clinical Trials

Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation

Start date: April 18, 2020
Phase:
Study type: Observational [Patient Registry]

The aim of the study will be to analyze the microbiome in the blood and stomach in patients with intestinal metaplasia (IM) and / or gastric cancer (GC). As far as IM is concerned, it has been found that the incomplete type is related to GC mainly intestinal-type. Studies show differences in the microbiome in patients with IM and in patients with GC, but do not specify whether these differences are related to histological types. Our intention is to further analyze the microbiome based on histological types. Most studies on stomach cancer have focused on the microbiota of gastric microbiota. Recent data have shown that the microbiome of the small intestine, especially the mucosa, can play a key role in the condition of the gastrointestinal tract. Disturbance of the microbiome of the small intestine has been found in celiac disease, chronic liver disease, diabetes and irritable bowel syndrome. However, information on the role of the microbiome in IM remains limited.