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Gabapentin clinical trials

View clinical trials related to Gabapentin.

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NCT ID: NCT06254183 Not yet recruiting - Acute Kidney Injury Clinical Trials

Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy(LSG)

Start date: February 2024
Phase: Phase 1/Phase 2
Study type: Interventional

Assessment of the effect of gabapentin as an analgesic replacement on the Kidney function following Laparoscopic sleeve gastrectomy for Morbid Obese Patients by measuring two biomarkers: NGAL (Neutrophil gelatinase-associated lipocalin)and DKK3 (Dickkopf-3)

NCT ID: NCT06112223 Not yet recruiting - Postoperative Pain Clinical Trials

Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy

Start date: November 10, 2023
Phase: N/A
Study type: Interventional

The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

NCT ID: NCT05301205 Enrolling by invitation - Gabapentin Clinical Trials

Perioperative Administration of Gabapentin for Reducing Inhalational Anesthetic Consumption

Start date: June 25, 2021
Phase: Early Phase 1
Study type: Interventional

Gabapentin, a structural analog of gamma aminobutyric acid (GABA), was introduced within the us as an anticonvulsant, used clinically to treat epilepsy. The drug causes amino acids release within the medulla spinalis dorsal horn and thus decreasing response to neural inputs and stabilizing the nervous activity. The mechanism of action of gabapentin on neuropathic pain is assumed to bind to the alpha 2 delta subunit of the voltage-dependent calcium channel within the central systema nervosum , reducing calcium influx into the nerve terminals and decreases the release of neurotransmitters like glutamate . Gabapentin, therefore, can be used for controlling chronic pain, as in diabetic neuropathy and other neuropathic disorders . Some studies examined the effectiveness of gabapentin for acute postoperative pain management for gynecological surgery, lumbar spinal surgery, arthroplasty, and thoracic surgery . A recent study concluded that gabapentin has a role in preoperative anxiolysis, attenuation of hemodynamic response to intubation, prevention of postoperative nausea and vomiting (PONV) and finally postoperative delirium . Up to date, the effect of preoperative gabapentin on inhaled anesthetic depth is unknown

NCT ID: NCT04855578 Completed - Polypharmacy Clinical Trials

Deprescription of Gabapentinoids in Medical Inpatients

GABA-WHY
Start date: May 28, 2021
Phase: N/A
Study type: Interventional

In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care hospitals in Montréal, Canada. This intervention will be supplemented by a brief information session for medical staff on the wards. This study aims to evaluate the effectiveness of this combined intervention on increasing gabapentinoid deprescription rates among study participants compared to control following hospital discharge.

NCT ID: NCT04705480 Recruiting - Pain Clinical Trials

Pregabalin vs. Gabapentin on Reducing Opioid Usage

Start date: April 12, 2021
Phase: Phase 4
Study type: Interventional

This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease the amount of opioid pain medication usage in single-system orthopedic trauma patients.

NCT ID: NCT02987985 Completed - Anesthesia Clinical Trials

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

Start date: October 15, 2017
Phase: Phase 3
Study type: Interventional

The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the post-anesthesia care unit and ward in children with sleep-disordered breathing undergoing tonsillectomy when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative respiratory depression in children with sleep-disordered breathing.