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Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy

Postoperative Pain Clinical Trial

Official title:
Preemptive Oral Gabapentin Versus Tramadol on Postoperative Pain After Knee Arthroscopy Done Under Spinal Anesthesia: A Prospective Randomized Trial

Clinical Trial Summary

The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

Clinical Trial Description

Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic. Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics. Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety. Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06112223
Study type Interventional
Source Tanta University
Contact Laila A El-Ahwal, MD
Phone 00201018484319
Email lailaelahwal@gmail.com
Status Not yet recruiting
Phase N/A
Start date November 10, 2023
Completion date May 1, 2024
View Details
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