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Edema clinical trials

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NCT ID: NCT01698619 Recruiting - Clinical trials for Acute Mountain Sickness

Hemodynamic Changes in Altitude Adaptation

Start date: August 2012
Phase: N/A
Study type: Observational

We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of acclimatization on a expedition to Mount Aconcagua.

NCT ID: NCT01635790 Recruiting - Clinical trials for Diabetic Macular Edema

Comparing the Effectiveness and Costs of Bevacizumab to Ranibizumab in Patients With Diabetic Macular Edema (BRDME)

BRDME
Start date: June 2012
Phase: Phase 2/Phase 3
Study type: Interventional

The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with DME (OCT central area thickness > 275 μm) as determined by the change in best-corrected visual acuity (BCVA) in the study eye from baseline to month 6.

NCT ID: NCT01574911 Recruiting - Lymphedema Clinical Trials

Validation of a New Method of Limb Volumetry

Start date: April 2012
Phase: N/A
Study type: Observational

Volumetry is essential for the diagnosis and follow-up of patients with limb edema. The objective of this project is the validation of real-time reconstruction and calculation of limb volume using a 3D laser scanner. Water - displacement volumetry (water-filled boot) is the reference method with known accuracy and reproducibility, but is not commonly used in clinical practice because it is cumbersome, difficult, and time-consuming. The most commonly used method remains segmental limb perimetry with a tape measure, followed by volume calculation using the truncated cones formula, thus excluding de facts extremities (hands and feet) which can neither be likened to cones nor easily measured. Quantification limb volume and volume changes is essential for the diagnosis and follow-up of patients with chronic venous insufficiency or lymphedema, two very common pathological conditions. It is mandatory for the evaluation of therapeutic approaches. The present study will use an innovative technology of volume acquisition by freehand laser scanning with a hand-held camera with Quantification limb volume and volume changes is essential for the diagnosis and follow-up of patients with chronic venous insufficiency or lymphedema, two very common pathological conditions. It is mandatory for the evaluation of therapeutic approaches. The present study will use an innovative technology of volume acquisition by freehand laser scanning with a hand-held camera with real-time 3D reconstruction. Its advantages are non-contact, accurate and detailed quantification of edema, including extremities, allowing to assess the magnitude and topography of physiological, pathological, or treatment - induced volume changes. This approach will ultimately provide data that will used for designing personalized limb compression ortheses.

NCT ID: NCT01283568 Recruiting - Depression Clinical Trials

Safety and Efficacy Study of Gamaline+Hipericin in PMS

GH
Start date: January 2011
Phase: N/A
Study type: Observational

GAMALINE is already register for PMS and HIPERICIN as antidepressive drug. Both plant extracts. The investigators will try the mixture and see if the vasomotor symptoms will disappear. The investigators expect that together all symptoms will be covered better than Gamaline alone. The investigators will run for 180 days measuring at T0, T1 and T6 (starting point, 30 days and 180 days).

NCT ID: NCT01269177 Recruiting - Clinical trials for Respiratory Insufficiency

Mortality and Risk Factors in Patients With Acute Cardiogenic Pulmonary Edema: a Multicentric, Observational, Prospective Study

ACPE
Start date: May 2009
Phase: N/A
Study type: Observational

The purpose of this study is to define the current treatment of patients ospitalized with acute cardiogenic pulmonary edema. Clinical and laboratory data collected in the Emergency Department will used to investigate the primary outcome (mortality) and risk factors related to the primary outcome.

NCT ID: NCT01218750 Recruiting - Clinical trials for Diffuse Diabetic Macular Edema

Triple Therapy for Diffuse Diabetic Macular Edema

TTDDME
Start date: December 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety end efficacy of combined phakoemulsification and vitrectomy with retinal endophotocoagulation and intraoperative use of bevacizumab in patients with diffuse diabetic macular edema (DDME), to determine the possible preoperative and intraoperative factors that might influence surgical outcomes.

NCT ID: NCT01123564 Recruiting - Macular Edema Clinical Trials

Efficacy and Safety of Lucentis for Clinically Significant Macular Edema Secondary to Central Retinal Vein Occlusion

BRAVO
Start date: August 2009
Phase: Phase 2
Study type: Interventional

This study aims to assess if Lucentis injection applied into the eye is superior to conventional treatment concerning the prevention of visual loss in patients having clinically significant macular edema secondary to retinal vein occlusion

NCT ID: NCT01112150 Recruiting - Heart Failure Clinical Trials

Effect of Normatec Pump for Relief of Leg Edema

Start date: April 2010
Phase: N/A
Study type: Interventional

The investigators hypothesize that leg edema will decrease rapidly when using the NormaTec pump, patients will lose weight, will feel better, will be less prone to infections in their legs and to congestion of the liver. Temporary elevation of intravascular fluid volume by the mobilized edema fluid returned to the intravascular space by pumping may increase cardiac output and renal perfusion and in addition it may distend the right atrium and ventricle thus inducing BNP secretion. Both mechanisms may promote excess fluid removal by the kidneys.

NCT ID: NCT01077401 Recruiting - Clinical trials for Diabetic Macular Edema

Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 With High Dose - the READ 3 Study

READ 3
Start date: February 2010
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the safety, tolerability, bioactivity, and dose response of two different dosages (0.5 mg and 2.0 mg) of ranibizumab (RBZ) in patients with diabetic macular edema (DME).

NCT ID: NCT01045239 Recruiting - Clinical trials for Diabetic Macular Edema

Micropulse 577 nm Laser Photocoagulation Versus Conventional 532 nm Laser Photocoagulation for Diabetic Macular Oedema

UMDMO
Start date: October 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether the new micropulse 577 nm yellow laser is a better treatment option compared to the conventional 532 nm green laser for diabetic macular edema.