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Neuromodulation in Patients With Neuropathic Pain and Depression. — DOLODEP  

Depression Clinical Trial

Official title:
Neuromodulation in Patients With Neuropathic Pain and Depression: a Cross-over Study Between Two Targets in Transcranial Magnetic Stimulation, the Primary Motor Cortex and the Dorsolateral Prefrontal Cortex.

Clinical Trial Summary

High-frequency repetitive transcranial magnetic stimulation of the primary motor cortex has shown its effect on refractory neuropathic pain, and rTMS of the dorsolateral prefrontal cortex is commonly used for treatment-resistant depression. The treatment for patients suffering from neuropathic pain and depression, concomitantly, still needs to be studied, as there are some specificities in both symptoms and brain functional MRI.

Clinical Trial Description

This project is a cross-over study for these patients, including 4 sessions of either M1 or DLPFC rTMS, a wash-out period, followed by 4 sessions of the other stimulation site, to assess the efficiency of a DLPFC rTMS for neuropathic pain with a comorbid depression. Besides pain intensity and quality, patient's mood, quality of life, and catastrophizing will be assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06129890
Study type Interventional
Source Centre Hospitalier Universitaire de Saint Etienne
Contact Roland PEYRON, PhD
Phone (0)4 77 12 78 05
Email roland.peyron@univ-st-etienne.fr
Status Recruiting
Phase N/A
Start date April 26, 2024
Completion date March 2029
View Details
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