Depression, Anxiety and Social Relationships as Risk Factors for Dementia

Depression Clinical Trial

Official title:

Depression as Risk Factor for Dementia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04786561
• Other study ID #: 181011
• Status: Completed
• Start date: January 1, 2020
• Est. completion date: January 1, 2024

Study information

• Verified date: March 2024
• Source: Norwegian Centre for Ageing and Health
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. This risk factors, and efforts to reduce them are described through a follow up over three decades.

Description:

The Health Study in Nord-Trondelag (HUNT) fulfils most of the key requirements of a population-representative cohort study by meeting the following elements: firm knowledge about the population denominator, knowledge about reasons for refusal (in line with previous methods in HUNT), options for levels and localisation of participation (at test station, at home, at nursing homes), coverage of sociodemographic features by the comprehensive HUNT4-protocol and register linkage, inclusion of institutionalized individuals and individuals with reduced capacity to consent, measurement of risk and compensatory factors across the life course by merging with previous results in HUNT surveys and linkage to registries, core elements and assessment methods can be compared with other European populations studies including elderly people, and finally, the ability to include biobank results in the data analysis. The HUNT data supplemented by register linkage include all established and suspected risk factors of dementia.

A particular focus on primary health care is appropriate because it is in this part of the health care system that the need for extra resources due to the substantial increase in dementia prevalence is most pronounced. Furthermore, preventive measures in a life-course perspective will mainly have to be implemented in the primary health care setting.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11000
• Est. completion date: January 1, 2024
• Est. primary completion date: January 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• Living in designated area

Exclusion Criteria:

• None

Related Conditions & MeSH terms

• Alzheimer Disease
• Anxiety
• Dementia
• Dementia Alzheimers
• Depression
• Depressive Disorder
• Loneliness
• Risk Factor
• Social Isolation

Locations

Country	Name	City	State
Norway	Norwegian national advisory unit on Ageing and Health	Tønsberg

Sponsors (5)

Lead Sponsor	Collaborator
Norwegian Centre for Ageing and Health	Norwegian Health Association, Norwegian Institute of Public Health, Norwegian University of Science and Technology, University College, London

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of dementia diagnosis in HUNT4 70+ study	Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.	2017-2019
Primary	Incidence of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study	Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.	2017-2019
Secondary	Change in loneliness	Self-reported feeling of loneliness	1995-2019