Depression Clinical Trial
Official title:
Prevalence and Independent Predictors of Depression in COPD
Depression adversely affects quality of life in COPD patients, associated with higher rate
of exacerbations, admissions and mortality. However, local prevalence rate of depression in
geriatric COPD patients remains unknown.
Though BODE index is superior to FEV1 in prediction of depression in COPD, it is unclear
which domain of BODE correlates best with depression. Furthermore, with multiple confounding
factors, it's ambiguous that whether frequent exacerbation is an 'independent' predictor for
depression among COPD patients.
The objective of this study is i.) to study the local prevalence rate of depression in
geriatric COPD patients, ii.) to identify risk factors for depression especially looking at
the any independent relationship between frequent exacerbations, various domains of BODE
index and depression.
This study is a multi-centers, cross-sectional study, conducted in Kwong Wah Hospital and Wong Tai Sin Hospital, Hong Kong SAR. Age and comorbidity-matched COPD and control subjects were recruited from clinics. Depressive symptoms were measured by a validated Chinese version of Geriatric Depression Scale short form (GDS - 15 items) with 2 cut-off points. A score of 8 or above was considered significant depressive symptoms while the cut off score of 5 or above was for patients with mild depressive symptoms. Prevalence rates of depressive symptoms were measured in both COPD and control groups. Predictors for depression (GDS = or> 8) were determined using univariate and multivariate analysis. ;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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