Prevalence and Predictors of Depression in COPD

Depression Clinical Trial

Official title:

Prevalence and Independent Predictors of Depression in COPD

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02415140
• Other study ID #: KW/EX-13-142 (70-02)
• Status: Completed
• Phase: N/A
• First received: April 8, 2015
• Last updated: April 13, 2015
• Start date: October 2013

Study information

• Verified date: April 2015
• Source: Kwong Wah Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Hong Kong: Ethics Committee
• Study type: Observational

Clinical Trial Summary

Depression adversely affects quality of life in COPD patients, associated with higher rate of exacerbations, admissions and mortality. However, local prevalence rate of depression in geriatric COPD patients remains unknown.

Though BODE index is superior to FEV1 in prediction of depression in COPD, it is unclear which domain of BODE correlates best with depression. Furthermore, with multiple confounding factors, it's ambiguous that whether frequent exacerbation is an 'independent' predictor for depression among COPD patients.

The objective of this study is i.) to study the local prevalence rate of depression in geriatric COPD patients, ii.) to identify risk factors for depression especially looking at the any independent relationship between frequent exacerbations, various domains of BODE index and depression.

Description:

This study is a multi-centers, cross-sectional study, conducted in Kwong Wah Hospital and Wong Tai Sin Hospital, Hong Kong SAR. Age and comorbidity-matched COPD and control subjects were recruited from clinics. Depressive symptoms were measured by a validated Chinese version of Geriatric Depression Scale short form (GDS - 15 items) with 2 cut-off points. A score of 8 or above was considered significant depressive symptoms while the cut off score of 5 or above was for patients with mild depressive symptoms. Prevalence rates of depressive symptoms were measured in both COPD and control groups. Predictors for depression (GDS = or> 8) were determined using univariate and multivariate analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 161
• Est. primary completion date: February 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• aged 60 or above,

• with stable COPD suggested clinically and

• post-bronchodilator spirometry FEV1/FVC ratio <0.7.

Exclusion Criteria:

• Patients were excluded if they had co-existing pulmonary diseases like active pulmonary tuberculosis, interstitial lung diseases etc;

• if they were too demented or physically incapacitated to participate e.g wheelchair-bound for bedbound.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• COPD
• Depression
• Depressive Disorder

Intervention

Other:
• Rate of depression

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kwong Wah Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of depression (Prevalence rate)		1 year	No