Depression Clinical Trial
Official title:
Phase One: An Open Trial of Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depression
Pregnant women with histories of depression are at high risk of depressive relapse during the
perinatal period, and options for relapse prevention are limited. Mindfulness-based cognitive
therapy (MBCT) has strong evidence among general populations but has not been studied among
at risk pregnant women.
This study is the first phase of a multi-phase project adapting MBCT for perinatal women
(MBCT-PD). It is being conducted in a collaboration between the University of Colorado, Emory
University, and Kaiser Permanente at Colorado and Georgia.
Mindfulness-based cognitive therapy (MBCT) represents one of the most important recent
developments in the effort to prevent recurrent depression. Explicitly designed to modify
core underlying vulnerability factors among recovered individuals with histories of
depression, MBCT may have high applicability to the prevention of perinatal depression (PD).
During this phase of the project the investigators will employ an iterative process to
develop, within routine obstetric clinical settings, the MBCT-PD program across a two-center
open trial of pregnant women at high risk of perinatal depression. During this phase, the
investigators will modify the standard MBCT approach to be sensitive and specific to women at
high risk of perinatal depressive relapse or recurrence based on previous history of
depression and will address the following aims:
- Specific Aim 1: To examine the feasibility of MBCT-PD with respect to identification and
enrollment of women at-risk of perinatal depression based on a history of depression.
- Specific Aim 2: To examine the engagement of women with the MBCT-PD approach with
respect to retention, completion of daily practice assignments, and satisfaction
- Specific Aim 3: To examine the clinical outcomes including change in depression symptom
levels and rates of relapse/recurrence over the course of the intervention and through a
6-month postpartum follow-up.
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