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NCT ID: NCT04833972 Recruiting - Alcohol Drinking Clinical Trials

Eliciting Perceived Norms About Substance Use

Start date: February 10, 2021
Phase: N/A
Study type: Interventional

Survey experiment to elicit perceived norms about substance use

NCT ID: NCT04832321 Recruiting - Clinical trials for Alcohol Use Disorder (AUD)

Measuring Beliefs and Norms About Persons With Alcohol Use Disorder

Start date: February 19, 2021
Phase: N/A
Study type: Interventional

Survey experiment to estimate drivers of stigma toward people with alcohol use disorder

NCT ID: NCT04832243 Recruiting - Food Deprivation Clinical Trials

List Experiment to Measure Food and Water Insecurity

Start date: February 19, 2021
Phase: N/A
Study type: Interventional

List experiment to measure food and water insecurity

NCT ID: NCT04825327 Not yet recruiting - Tuberculosis Clinical Trials

Predicting the Future: Incipient Tuberculosis

PreFIT
Start date: April 6, 2021
Phase:
Study type: Observational [Patient Registry]

The investigators will study, prospectively, if contacts (household or close contacts) of tuberculosis (TB) patients with high C-reactive protein (CRP), low hemoglobin (Hb) levels, and a positive Xpert Host Response (HR) cartridge result develop active TB within 12 months. They will also investigate if there is a correlation between progressing to active TB within 12 months and having high levels of the iron homeostasis markers (Hepcidin, Ferritin and Transferrin). Identified index cases who agree to participate will refer their household or close contacts to also join the study. These contacts will be tested for TB and only contacts who are negative will be enrolled and followed-up at 6 months and 12 months. Blood samples will be collected at baseline and 6 months for testing. During the study period, TB testing will be done on contacts who meet symptoms criteria. At 12 months, all contacts will undergo a chest x-ray to assist in the diagnosis of TB. PreFIT will target people aged 12 to 60 years of age and both HIV negative and positive. 1515 trial participants will be recruited at Stellenbosch University in South Africa, 1515 at Fundaçao Manhiça in Mozambique and 1010 at Makerere University in Uganda, respectively.

NCT ID: NCT04824131 Recruiting - HIV Infections Clinical Trials

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Females - A Sub-study of HPTN 084

Start date: November 4, 2020
Phase: Phase 2
Study type: Interventional

This study will establish the minimum safety, tolerability and acceptability data needed to support the use of cabotegravir long-acting injection (CAB LA) in an adolescent population, potentially transforming the field of HIV prevention for young people.

NCT ID: NCT04813159 Not yet recruiting - STEMI Clinical Trials

Remote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA

RIC-AFRICA
Start date: May 2021
Phase: N/A
Study type: Interventional

The RIC-AFRICA study is a sub-Saharan African prospective, multi-centre, randomised, sham-controlled, clinical trial of 1200 ST-segment elevation myocardial infarction (STEMI) patients undergoing predominantly thrombolytic therapy in 18 sites across South Africa, Kenya, Sudan and Uganda. The purpose of the study is to determine whether Remote Ischaemic Conditioning (RIC) can reduce the rates of all-cause death and early post-myocardial heart failure at 30-days in STEMI patients treated predominantly with thrombolytic therapy.

NCT ID: NCT04810650 Not yet recruiting - Hypertension Clinical Trials

A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa

SAPPHIRE
Start date: April 2021
Phase: N/A
Study type: Interventional

The overall objective is to determine to reduce HIV incidence and to improve community health with multi-sector, scalable interventions. This study will consist of two phases: Phase A, in which randomized trials will assess effectiveness, fidelity and cost and improve context-specific "fit" of prevention and treatment interventions. Combining effectiveness with implementation, costing and modelling outcomes, Phase A will optimize intervention packages with context specific adaptations in structured consultation with stakeholders. Phase B, which will evaluate the effects of these optimized dynamic prevention and treatment packages, alone and in combination, on prevention coverage, population-level suppression, and HIV incidence, as well as other health outcomes, in a balanced, community randomized 2x2 factorial design. This clinicaltrial.gov registration is for Phase A.

NCT ID: NCT04782011 Not yet recruiting - ATC/DDD Clinical Trials

Using the ATC/DDD to Monitor Antibiotic Use at Lower Primary Care Facilities in Southwestern Uganda

Start date: March 2021
Phase: N/A
Study type: Interventional

This is a non blinded two arm cluster randomized control trial, aimed at assessing the feasibility of using the Anatomical Therapeutic Chemical Classification/define Daily Doses system tool to monitor antibiotic use at lower primary levels of care in Uganda.

NCT ID: NCT04774666 Not yet recruiting - HIV Testing Clinical Trials

Caregiver-Assisted Oral Fluid-based HIV Screening in Children: Uganda

Start date: March 1, 2021
Phase:
Study type: Observational

The purpose of this study is to evaluate the acceptability, feasibility and effectiveness of a caregiver-assisted oral fluid-based HIV test to screen children for HIV. The results of this study are intended to support expanded access to HIV testing and treatment services for children, and to ensure that all newly diagnosed children are linked to clinical care.

NCT ID: NCT04771325 Recruiting - Labor Long Clinical Trials

Assessment of the Effectiveness of Continuous Labour Support by a Trained Companion of Choice on Events of Labor and Maternal Satisfaction in the Bugisu Sub Region, Uganda

Start date: December 30, 2019
Phase: N/A
Study type: Interventional

A randomized control trial employing a cross sectional stepped wedge design. Women with anticipated vaginal delivery, receiving usual care for the control group while women receiving usual care plus support from a trained companion will constitute the experimental group. Events and outcomes will then be assessed during and after birth.