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NCT ID: NCT05426980 Recruiting - Multiple Sclerosis Clinical Trials

Artificial Intelligence in Predicting Progression in Multiple Sclerosis Study

AI ProMiS
Start date: December 13, 2021
Phase:
Study type: Observational

The study proposal focuses on multiple sclerosis (MS), a chronic incurable disease of the central nervous system (CNS). The MS disease is characterised by recurrent transient disability progression, quantified by increase in the extended disability status score (EDSS), and subsequent remission (disappearance of symptoms and reduced EDSS score) or, alternatively, a gradual EDSS disability progression and exacerbation of associated symptoms. At the same time, the MS is characterised by multifocal inflammatory lesions disseminated throughout the white and grey matter of the CNS, which can be observed and quantified in the magnetic resonance (MR) scans. The proposed study will address the critical unmet need of computer-assisted extraction and assessment of prognostic factors based from an individual patient's brain MR scan, such as lesion count, volume, whole-brain and regional brain atrophy, and atrophied lesion volume, in order to evaluate the capability for personalized future disability progression prediction.

NCT ID: NCT05389618 Enrolling by invitation - Obesity Clinical Trials

Dietary Challenges in the Population of Nursing Homes' Residents

NUTRICARE
Start date: May 23, 2022
Phase:
Study type: Observational

To obtain up-to-date data on nutritional status of older adults, a national dietary survey will be conducted in 2022/2023, providing data on the consumption of foods and enabling the assessment intakes of energy and specific nutrients. Participating subjects will be also screened for micronutrient status using blood biomarkers (focusing into vitamin D, folic acid, vitamin B12, and iron).

NCT ID: NCT05377164 Recruiting - Clinical trials for Asymptomatic Condition

Long Term Effects of Different Dietary Protocols on Determinants of Health in Patients' Lymphocytes

FTIR
Start date: May 20, 2022
Phase:
Study type: Observational

Food choices and eating habits play an important role in the management of common noncommunicable diseases, i.e. diabetes type II, hypertension, metabolic syndrome and others. However, for many popular diets there is yet no consensus on their actual ability to exert health effects and, regardless of some promising results, the underlying molecular mechanisms are not entirely clear. FTIR analysis could provide interesting new information; we therefore propose the analysis of lymphocytes isolated from the peripheral blood of participants who had been on vegan, ketogenic or normal mixed diet for at least one year. In particular we plan to monitor differences in lipid peroxidation, membrane permeability, protein synthesis and DNA damage. All these parameters are important in the development of the above mentioned diseases and were previously shown to be detectable by FTIR. The results will contribute importantly to the understanding of the long-term effects of the respective lifestyle and will allow the formulation of better dietary recommendations to the public.

NCT ID: NCT05359640 Completed - Lower Back Pain Clinical Trials

Invasive Treatment of Lower Back Pain

Start date: April 15, 2022
Phase:
Study type: Observational

Lower back pain, especially chronic, is a very complex condition that has different causes. There is no single pathophysiological mechanism that could explain the causes of low back pain. It is deffined as non-specific and results in only symptomatic treatment. The mechanisms ob pain overlap and combine with genetic, epigenetic, individual factors and lifestyle. On the other hand, when low back pain have a defined cause, the treatment can be causal. At the beginning of the treatment of patients with non-specific low back pain, identification of those that would probably need more complex treatment was tried.More complex patients are also referred to physiotherapy, and those who are more likely to develop chronic back pain, should be also referred to a psychologist. An important place to terminate the back pain cycle has spine blockades, either local, trigger points blockades, or x-ray-guided blockades of facet joints or nerve roots.

NCT ID: NCT05351918 Completed - Migraine Clinical Trials

Comparison of Two Different Migraine Acupuncture Treatment

Start date: February 1, 2022
Phase:
Study type: Observational

Headache is one of the most common clinical problems. Conventional drug therapy is more successful when complementary and integrative medicine approaches are combined to conventional treatment, as traditional Chinese medicine (TKM). The success of acupuncture therapy depends on the selection of acupuncture points according to TKM pathological mechanisms. Correct selection of points are needed to treat migraine headaches.Acupuncture reduces the consumption of analgesics. In this prospective, randomised study we will compered two methods of acupuncture stimulation: in the control group, all patients will receive the same local points, commonly used to treat migraine in our department, in the study group, local points will be selected according to the site of the headache.

NCT ID: NCT05339308 Not yet recruiting - Magnesium Clinical Trials

Effects of Magnesium Oil Application on the Muscle Contractile Properties

MG-MCP2022
Start date: June 1, 2022
Phase: N/A
Study type: Interventional

This study will aim to investigate the effects of magnesium oil administration on skeletal muscle contractile properties.

NCT ID: NCT05336760 Not yet recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Dysphagia, QoL and Attitudes Towards PEG in ALS Patients

ALSDPEG
Start date: May 31, 2022
Phase:
Study type: Observational

In Amyotrophic Lateral Sclerosis, dysphagia has a high incidence. With deterioration of swallowing function, percutaneous endoscopic gastrostomy (PEG) tube is recommended to ensure sufficient and safe oral intake. Dysphagia and PEG placement alter quality of life (QoL). However, QoL and attitudes toward PEG remain largely unexplored. The purpose of this study is to monitor the swallowing function in relationship to QoL and attitudes toward PEG tube insertion and feeding.

NCT ID: NCT05335902 Recruiting - Cardiac Disease Clinical Trials

Optic Nerve Sheath After Extracorporeal Circulation

Start date: November 22, 2021
Phase:
Study type: Observational

The purpose of this study is to assess the influence of extracorporeal circulation during cardiac surgery on the optic nerve sheath diameter (ONSD) after the surgery.

NCT ID: NCT05333315 Recruiting - Hypertension Clinical Trials

Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults

FOODSU
Start date: April 20, 2022
Phase: N/A
Study type: Interventional

In recent years, dietary supplement are of great interest for the improvement of human health. This study is designed as a parallel, randomized, double blind study exploring the efficacy of two months daily oral dosing of five different food supplements together with diet restriction in 120 otherwise healthy overweight or obese adults on different biochemical and anthropometric parameters.

NCT ID: NCT05320354 Enrolling by invitation - Clinical trials for Periprosthetic Joint Infection

Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID

MID
Start date: April 25, 2022
Phase:
Study type: Observational

The primary objective of this study is to demonstrate the validity of the Microbial- ID test to aid in diagnosis of periprosthetic joint infection (PJI) in terms of sensitivity and specificity.