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NCT ID: NCT04001348 Completed - Healthy Clinical Trials

Characteristics of Different Types of Safety Lancets on Blood Volume and Perceived Pain in Male and Female Volunteers

Start date: June 2013
Phase: N/A
Study type: Interventional

The study was a randomized, single blind, uni-center pivotal study in male and female healthy volunteers, to determine capillary blood volume and pain perception obtained in a process of puncturing with different safety lancets. A group of one hundred (100) healthy Caucasian male and female Subjects (aged > 18 to < 65 years old was randomized ) who were in good physical and mental condition. The Subjects had 4 (four) fingers (two fingers from each hand) lanced each with a different type of safety lancet. Overall, 4 (four) different safety lancets were investigated per each Subject. Overall, 16 (sixteen) different safety lancets (4 different safety lancets per one Subject) were investigated, the capillary blood volume and pain were measured.

NCT ID: NCT04000126 Completed - Pain Clinical Trials

Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious

Start date: February 25, 2019
Phase: N/A
Study type: Interventional

This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.

NCT ID: NCT03999918 Completed - Clinical trials for Adjunctive Treatment of Major Depressive Disorder

Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Start date: July 8, 2019
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy and safety of adjunctive pimavanserin compared to placebo in subjects with major depressive disorder who have an inadequate response to antidepressant therapy.

NCT ID: NCT03998449 Completed - Clinical trials for Inflammatory Bowel Diseases

Immunogenicity of Cholera Vaccine in Children With IBD

Start date: August 30, 2017
Phase: N/A
Study type: Interventional

Assessment of the immunogenicity and safety of immunization against cholera in children with inflammatory bowel disease.

NCT ID: NCT03998163 Completed - Uremic Pruritus Clinical Trials

CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus

Start date: May 6, 2019
Phase: Phase 3
Study type: Interventional

This is a multicenter, open-label study to evaluate the safety and effectiveness of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session. The study includes an up to 12-week Treatment Period.

NCT ID: NCT03996447 Completed - Clinical trials for Blood Brain Barrier Defect

Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

PICTURE
Start date: June 3, 2019
Phase: Phase 3
Study type: Interventional

the trial aims to evaluate the Efficacy and Safety of gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

NCT ID: NCT03996369 Completed - Ulcerative Colitis Clinical Trials

Etrasimod Versus Placebo as Induction Therapy in Moderately to Severely Active Ulcerative Colitis

ELEVATE UC 12
Start date: September 15, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy of etrasimod on clinical remission in participants with moderately to severely active ulcerative colitis (UC).

NCT ID: NCT03994640 Completed - Clinical trials for Temporomandibular Disorder

Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD

Start date: January 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD

NCT ID: NCT03994211 Completed - Solid Tumor Clinical Trials

Study to Investigate the Effect of Rifampin and Itraconazole on the Action of Pamiparib in Participants With Cancer

Start date: May 29, 2019
Phase: Phase 1
Study type: Interventional

The study was an open-label, parallel-group, fixed-sequence study in male and female cancer patients. The study consists of 2 phases: the Core Phase, which is divided into Part A and Part B, and the Extension Phase. Part A investigated the effect of CYP3A induction by rifampin on the single dose pharmacokinetics (PK) of pamiparib, and Part B investigated the effect of CYP3A inhibition by itraconazole on the single dose PK of pamiparib. Participants were offered participation in the Extension Phase, in which they received pamiparib until progression of disease, unacceptable toxicity, withdrawal of consent, or any other reason for discontinuation.

NCT ID: NCT03992846 Completed - Endometriosis Clinical Trials

Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain.

Start date: June 13, 2019
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to demonstrate the efficacy and safety of linzagolix administered orally once daily for 3 months at a dose of 75 mg alone or of 200 mg in combination with add-back hormone replacement therapy (ABT: estradiol (E2) 1 mg / norethisterone acetate (NETA) 0.5 mg) versus placebo, in the management of moderate to severe endometriosis-associated pain (EAP).