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NCT ID: NCT03404063 Recruiting - Clinical trials for Myocardial Infarction

Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With Acute Myocardial Infarction (AMI)

Start date: October 20, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The main objective of the CIRCULATE project is to compare the clinical outcomes of CardioCell administration in treatment of ischemic damages of cardiovascular system with control group, who will be treated by the administration of placebo during the sham procedure.

NCT ID: NCT03403205 Not yet recruiting - Wilson Disease Clinical Trials

Efficacy and Safety of WTX101 Administered for 48 Weeks Versus Standard of Care in Wilson Disease Subjects

Start date: January 31, 2018
Phase: Phase 3
Study type: Interventional

Wilson Disease (WD) is an autosomal recessive disorder of impaired copper (CU) transport caused by mutations in the ATP7B gene. WTX101 (bis-choline tetrathiomolybdate) is a first-in-class copper-protein-binding agent with a unique mechanism of action, under investigation as a novel therapy for WD. It is formulated as an enteric coated tablet (15 mg strength) for oral administration. The purpose of this study is to evaluate the efficacy of WTX101 administered for 48 weeks compared to standard of care (SOC) in WD subjects aged 18 and older.

NCT ID: NCT03402698 Recruiting - Clinical trials for Vitamin D Deficiency

Vitamin D Supplementation in Children

MeltD
Start date: January 9, 2018
Phase: N/A
Study type: Interventional

Prevalence of vitamin D deficiency in children in the northern country during winter season is very high (up to 90%). Vitamin D supplementation at a dose 600 -1000 IU/d is recommended in Polish children from September till April. However, there is shortage of studies in Polish children. The aim of the study is to assess the effectiveness of vitamin D supplementation in the prevention of vitamin D deficiency in Polish children (4-10 years of age).

NCT ID: NCT03401463 Recruiting - Clinical trials for Respiratory Tract Infections

Assesment of the Endotracheal Tube Cuff Pressure Values in ICU Pateints Before and After Training Seminar

Start date: October 26, 2017
Phase: N/A
Study type: Interventional

There is no accepted standard for the frequency of monitoring endotracheal tube cuff pressures (ETCP). the investigators plan on comparing two strategies for monitoring ETCP in mechanically ventilated patients. Nowadays ETCP is evaluated once every 24 hours. Next, the investigator want to conduct training for medical and nursing staff. After the training, ETCP will be measured every 8 hours. The aim of the study is to prove that more frequent pressure control (3 times a day) reduces the occurrence of abnormal ETCP.

NCT ID: NCT03401229 Not yet recruiting - Nasal Polyposis Clinical Trials

Efficacy and Safety Study of Benralizumab for Patients With Severe Nasal Polyposis

OSTRO
Start date: January 15, 2018
Phase: Phase 3
Study type: Interventional

The aim of this present study is to investigate the use of benralizumab as treatment for severe nasal polyposis. The effect of benralizumab on nasal polyps will be assessed over a 56 weeks of treatment period in patients with severe bilateral nasal polyposis who are still symptomatic despite standard of care therapy, i.e current use of intranasal corticosteroids (INCS) and prior surgery and/or use of systemic corticosteroids. The first 200 patients that complete the 56-week treatment will have a 6 month follow-up (FU) period without dosing.

NCT ID: NCT03400800 Recruiting - Clinical trials for Elevated Cholesterol

Inclisiran for Subjects With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol

ORION-11
Start date: November 1, 2017
Phase: Phase 3
Study type: Interventional

This is a Phase III, placebo-controlled, double-blind, randomized study in participants with ASCVD and elevated LDL-C despite maximum tolerated dose of LDL-C lowering therapies to evaluate the efficacy, safety, and tolerability of subcutaneous (SC) inclisiran injection(s). The study will be an international multicenter study (non-United States).

NCT ID: NCT03398356 Recruiting - PreDiabetes Clinical Trials

Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.

Start date: October 20, 2017
Phase: Phase 4
Study type: Interventional

This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000 mg/day.

NCT ID: NCT03393702 Recruiting - Pain, Postoperative Clinical Trials

Pain Control in Children and Adolescent After Thoracic Surgery: The Effect of Gabapentin

Start date: May 9, 2017
Phase: Phase 4
Study type: Interventional

The study is performed in patients aged 5-18 years after thoracic surgery. The primary aim of this study is to determine whether the use of gabapentin will improve postoperative multimodal analgesia and reduce consumption of ropivacaine with fentanyl or morphine in children and adolescent after the Ravitch procedure and thoracotomy. Secondary aims are to evaluate whether use of gabapentin reduces pain and anxiety scores, decreases postoperative nausea and vomiting, and improves patient satisfaction.

NCT ID: NCT03392402 Recruiting - Thyroid Cancer Clinical Trials

Molecular Classifier for the Fine Needle-based Assessment of Malignancy Risk in Thyroid Nodules

ThyroPred-1
Start date: January 1, 2017
Phase: N/A
Study type: Observational

This study evaluates the usefulness of molecular classifier to aid the diagnosis of malignancy in the material obtained by fine-needle aspiration biopsy (FNAB) of thyroid nodule. All participants will undergo FNAB with routine cytological assessment and molecular testing. Patients will undergo surgery or be followed-up, according to the clinical guidelines. The diagnostic power of combined molecular/clinical classifier will be compared to prediction based on clinical features only, by investigators blinded to the final diagnosis of surgical assessment.

NCT ID: NCT03389763 Recruiting - Clinical trials for Endoscopic Sinus Surgery

SPI-guided vs PRD-guided Analgesia During FESS for Intraoperative Blood Loss

Start date: June 1, 2016
Phase: N/A
Study type: Interventional

The aim of this randomized trial is to assess the efficacy of analgesia , compare the utility of Pupillary Dilatation Reflex (PRD), Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and their influence on intraoperative blood loss, quality of surgical field using Boezaart Bleeding Scale (BBS) in patients undergoing functional sinus surgery (FESS)