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NCT ID: NCT05051735 Not yet recruiting - Cancer Clinical Trials

PARASTOP - Paracetamol With Strong Opioids

PARASTOP
Start date: September 15, 2021
Phase: Phase 3
Study type: Interventional

Current guidelines recommend all people with cancer-related pain should be prescribed paracetamol, even those receiving high doses of strong pain killers (opioids) such as morphine. Although this has been shown in studies to be beneficial in other conditions, for instance dental work and after surgery, it has not been shown to further improve pain in people with cancer-related pain. We know that people can find taking tablets burdensome and we hope to determine whether the inconvenience of taking eight extra paracetamol tablets per day can be justified. In this study we plan to show whether or not pain control is changed (non-inferior) when stopping paracetamol compared to continued use of paracetamol in people already taking strong pain killers for cancer-related pain. We will do this by recruiting voluntary participants who are taking a combination of paracetamol and a strong opioid.

NCT ID: NCT05050708 Recruiting - Postoperative Pain Clinical Trials

Riskfactors of Post-operative Pain and Nausea After Ambulatory Gynaecological Laparocopy.

Start date: August 24, 2021
Phase:
Study type: Observational

Patient due for elective, ambulatory gynaecological laparoscopy will be screened peri-operatively for known and potential risk factors of postoperative pain and nausea/vomiting. The actual incidence and severity of pain and nausea/vomiting will be recorded during th 0-24 hr intervall after end of surgery, as well as the doses of all drugs, given for either prophylaxis or treatment

NCT ID: NCT05049759 Recruiting - Depression Clinical Trials

Physical Activity Intervention for Youth With Anxiety and Depression -Confident, Active and Happy Youth

CAH-Y
Start date: February 1, 2021
Phase: N/A
Study type: Interventional

Prevalence of mental health problems and disorders in children and adolescents (hereafter youths) are estimated at 13.4% of which anxiety and depressive disorders account for more than half of these disorders. These rates are increasing, putting a large strain on child and adolescent mental healthcare services (CAMHS) to provide cost-effective treatments with documented long-term effects. However, even when provided the best evidence based treatment, between 40-50 % do not recover and continue to report significant symptom burdens. Thus, there is an immediate need for supplementary and/or new treatment approaches. Physical activity as a supplementary treatment may be one such approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth. The current study will be based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. The study will initially focus on the first two phases of the MRC framework. In line with phase one of this framework, key intervention components have been identified in preliminary work, which draw on the effects of moderate to vigorous physical activity, inhibitory learning theory and self determination theory. These components are to be developed into an intervention to be used in CAMHS. Twenty youths with anxiety and/or depressive symptoms will be recruited to the intervention. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline and post-intervention. Outcome measures concerning symptom change will be assessed (anxiety and depression). Semi-structured qualitative interview with participants, caregivers and referring specialists will help identify possible contextual and practical factors associated with delivery of the intervention and explore acceptability of assessment procedures, the intervention, and perceived benefits and barriers to participation. This study will contribute to the development of evidence-based, patient-informed supplementary physical treatment interventions for youth with internalizing disorders in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of these disorders.

NCT ID: NCT05049356 Recruiting - Clinical trials for Attention Deficit Hyperactivity Disorder

Symptoms and Mechanisms of Child Psychiatric Disorders

Start date: June 26, 2020
Phase:
Study type: Observational [Patient Registry]

In this study the investigators will examine psychiatric symptoms, central neurocognitive functions, parental stress and attachment styles, and biological factors that can give new knowledge about some of the mechanisms present in children referred to outpatient psychiatric clinics. A specific focus will be given to children suffering from severe irritability.

NCT ID: NCT05049174 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Nurse-led Smoking Cessation Program With Follow-up in Healthy Life Centres: a Randomized Clinical Trial

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

A better understanding of how to incorporate effective smoking cessation into clinical practice is requested. In this is prospective, multi-center, randomized, open, blinded end-point trial, we assigned daily smokers hospitalized with an acute cardiac event 1:1 to an in-hospital nurse-led smoking cessation intervention with direct referral to further follow-up in the municipal healthy life-centres (intensive intervention) or to written information about smoking cessation and the municipal health service program (low-threshold intervention) . Both groups were prescribed varenicline from the hospital. The primary outcome will be the smoking cessation rates between the groups at 6 months follow-up. Key secondary outcomes include a cost-effectiveness analysis of the intensive intervention and cessation rates at 3- and 12-months follow-up, the proportion who used varenicline or nicotine replacement therapy and the proportion who attended the healthy-life center program between the two groups. Exploratory analyses include new knowledge about the patient and system factors of importance for participation to healthy life-centers and for changes in smoking behaviour.

NCT ID: NCT05049135 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Feasibility of a Sensor-less Sleep Monitor (Somnofy®) in Diagnosis and Follow-up in Obstructive Sleep Apnea.

Start date: September 2021
Phase:
Study type: Observational

To evaluate the feasibility of a sensor-less sleep monitor (Somnofy®) in diagnosis and follow-up in obstructive sleep apnea. The study will explore the monitor's usefulness in detection of apnea during sleep, and compare the data to standard diagnostic registrations.

NCT ID: NCT05044065 Not yet recruiting - Pancreatic Cancer Clinical Trials

Metabolic Stress-induced Exercise to Prevent Loss of Muscle Mass in Patients With Pancreatic and Biliary Tract Cancer

PREV-Ex
Start date: September 14, 2021
Phase: N/A
Study type: Interventional

In patients with cancer, resistance training appears to be a safe and effective exercise modality to increase both lean muscle mass and strength, as well as attenuates cancer-related fatigue. It may serve as a feasible intervention in these patients to mitigate cachexia, especially if implemented before the onset of cancer cachexia or in a pre-cachectic state. This study is a multicenter randomized controlled trial that will compare a metabolic-stress induced resistance training intervention during the pre- (prehabilitation) and post-operative (rehabilitation) phase in patients with pancreatic and biliary tract cancer, versus usual care on skeletal muscle and other health-related outcomes.

NCT ID: NCT05043701 Recruiting - Clinical trials for Recurrent Glioblastoma

Individualized Systems Medicine Functional Profiling for Recurrent Glioblastoma

ISM-GBM
Start date: October 2021
Phase: Early Phase 1
Study type: Interventional

A study to determine the feasibility and safety of individualized cancer stem cell targeted therapy based on high-throughput functional profiling of FDA/EMA-approved drugs in patients with GBM that has recurred or progressed following standards-of-care (RT, TMZ).

NCT ID: NCT05042414 Recruiting - Breastmilk Clinical Trials

Acute Effects of Endurance Exercise on Breastmilk Composition

ExMilk
Start date: August 24, 2021
Phase: N/A
Study type: Interventional

The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on the third day. The conditions will be randomly allocated to each participant. Breastmilk samples will be obtained in the morning of each test day, as well as immediately after, one hour after and four hours after the exercise/rest condition. Dietary intake will be standardized on the test days. At the time of study commencement, the trial (including planned analyses) is not fully funded. Additional milk will be stored for future analyses (not yet specified) when funding is secured.

NCT ID: NCT05042349 Not yet recruiting - Physical Activity Clinical Trials

Pregnant Elite Athletes and Pregnant Women Exercising With Moderate Intensity

Start date: November 1, 2021
Phase:
Study type: Observational

The aim of this study is to 1. register possible changes to uteroplacental circulation in relation to physical tests, 2. to register energy and nutritional intake, relationship towards the body during pregnancy and during the early period after giving birth, 3. register the experience of guidance given related to exercise, nutrition, and recovery, 4. register elite athletes' experience of combining the role of being a mom and an elite athlete, and 5. register attitudes and reactions from the support system when it comes to being an elite athlete and being pregnant. Material and method: 30 pregnant female elite athletes and 30 moderately physically active pregnant women will be recruited for the completion of physical testing and questionnaires and questionnaires only, respectively. 20 national team leaders/coaches and 10 sponsors will be recruited for a semi-structured interview about attitudes, reactions and guidance towards athletes who become pregnant and still wish to continue their career as an athlete after pregnancy.