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NCT ID: NCT03736577 Recruiting - Depression Clinical Trials

Psychotropic Drug Use in the Elderly Living in Nursing Homes and the Influence of a Structured Drug Review

Start date: November 2018
Phase: N/A
Study type: Interventional

The overall aim of this study is to explore if a structured drug review will change clinical symptoms and the psychotropic drugs prescription rate in the elderly living in nursing homes (participants of the study). The study will examine how training of nursing home physicians on reviewing prescription lists using the Norwegian general practice criteria - Nursing homes (NorGeP-NH) will influence the participants` clinical symptoms such as cognition, depression, anxiety and their quality of life. Secondary, we will analyse how a structured drug review will influence further psychotropic drug prescribing rates in nursing homes. The hypothesis for this study are: 1. Training of nursing home physicians on doing a systematic drug review will decrease the participants' clinical symptoms and improve their Quality of Life. 2. A systematic drug review will decrease the psychotropic drug prescription rates compared to before the drug review.

NCT ID: NCT03735615 Recruiting - Clinical trials for Pulmonary Disease, Chronic Obstructive

Sprint Interval Training in Patients With Chronic Obstructive Lung Disease

Start date: November 2018
Phase: N/A
Study type: Interventional

Exercise therapy is a cornerstone in the management of patients with Chronic Obstructive Pulmonary disease (COPD), and supervised walking exercise three times a week over 12 weeks improves walking ability and quality of life. Despite this, very few patients exercise on a regular basis. The underuse of exercise in COPD patients can partly be explained by discomfort during exercise because it evokes dyspnea, and thereby explain lack of participation in exercise. If the goal is to offer the best medical therapy to these patients, new and effective exercise training methods must be explored and defined since exercise training is an important part of pulmonary rehabilitation. Intention is to study a new training method called sprint interval training (SIT), which consists of high intensity bouts with very short duration. The idea behind SIT is to avoid the dyspnea associated with traditional endurance training, thus maximizing exercise power without excessive discomfort. The investigators will study training adaptations in patients with COPD and compare the results with age-matched controls. It is expected that both COPD-patients and healthy elderly will improve exercise cycle time until exhaustion after SIT training, and also that the improvement will be larger in the healthy group due to higher absolute training intensity.

NCT ID: NCT03732768 Not yet recruiting - Ovarian Cancer Clinical Trials

Study of Radspherin® in Recurrent Ovarian Cancer Subjects With Peritoneal Carcinomatosis

Start date: February 2019
Phase: Phase 1
Study type: Interventional

RAD-18-001 is a First-In-Man, Dose Escaltion study conducted at 2 sites. The dose escalation will be performed based on a 3 + 3 design. Increasing dose levels starting at 1 MBq will be followed by 2, 4 and 7 MBq. If the highest dose level of 7 MBq is reached without Dose Limiting Toxicicities (which will stop the dose escalation), this will be the recommended dose for further exploration. Acceptability of up to 7 MBq gives the opportunity to explore the doses of the dose escalation split into two administrations, and given as two separate injections 1 week apart. Split doses of 1, 2 and 3.5 MBq will be administered as two injections. Each subject will be followed until disease progression (in the abdominal cavity), or for 12 months after the administration of Radspherin® (whichever comes first).

NCT ID: NCT03730272 Recruiting - Post Traumatic Pain Clinical Trials

Occurence of Pain and Use of Analgesic Treatment in Multi-trauma Patients of Intermediate Seveity

Start date: August 1, 2018
Phase:
Study type: Observational

To register the perceived pain score during 0-14 days after multitrauma in conscious patients and to register the use (type and dose) of analgesic treatment in the same period.

NCT ID: NCT03730246 Recruiting - Pain Clinical Trials

Pain After Cesarean Sectio.

Start date: August 1, 2018
Phase:
Study type: Observational

To study the strength of postoperative pain 0-24 hrs after elective cesarean sectio in spinal anaesthesia.

NCT ID: NCT03730220 Recruiting - Induced; Birth Clinical Trials

The Norwegian Induction Project: a Pilot for a Prospective National Audit

Start date: September 1, 2018
Phase:
Study type: Observational

The worldwide rate of induction of labour has been steadily increasing over the last 15 years, a trend that is reflected in Norway. The overall aim of this study is to identify disparities between delivery departments in Norway in regards to: 1. The overall rate of labour induction 2. Main indication for the induction of labour. 3. Induction methods used and protocols followed 4. Maternal and fetal outcomes in induced births Methods: Observational study. Registration of induction indication, methods and outcomes in induced women. Data will be collected prospectively during a period of 4 months from 21 Norwegian delivery units using a web-based standardized case record form.

NCT ID: NCT03729557 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Cardiovascular Remodeling in Living Kidney Donors With Reduced Glomerular Filtration Rate

CENS
Start date: January 1, 2019
Phase:
Study type: Observational

Chronic kidney disease (CKD) is highly frequent, and patients with advanced CKD are known to have a high risk of developing cardiovascular disease (CVD). However, little is known about the cardiovascular risk in patients with mildly reduced kidney function (reduced glomerular filtration rate, GFR), affecting up to 10% of the general population; and importantly, also affecting living kidney donors. Until recently it has been believed that donating a kidney does not represent any health hazard. However, a recent Norwegian epidemiological study suggested that kidney donors have an increased risk of CVD. The pathogenesis linking reduced kidney function to CVD is not known. Living kidney donors provide a unique model for investigating the mechanisms underlying increased risk of CVD in patients with reduced GFR because living kidney donors are healthy before donation. Thus, the main purpose of the Project is to investigate the mekanismes underlying the development of cardiovascular remodelling induced by a reduction in GFR.

NCT ID: NCT03725202 Not yet recruiting - Clinical trials for Giant Cell Arteritis (GCA)

A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis

Start date: December 12, 2018
Phase: Phase 3
Study type: Interventional

This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured by the proportion of participants in sustained remission at Week 52, and to assess the safety and tolerability of upadacitinib in participants with giant cell arteritis (GCA). The objective of period 2 is to evaluate the safety and efficacy of continuing versus withdrawing upadacitinib in maintaining remission in participants who achieved remission in Period 1.

NCT ID: NCT03724162 Recruiting - Microcirculation Clinical Trials

Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis

Start date: July 16, 2018
Phase:
Study type: Observational [Patient Registry]

The incidence of anastomotic leaks after gastroesophageal anastomosis after thoracolaparoscopic cancer oesophagus surgery is high at the Oslo University Hospital. The patients selected for operation shall be investigated for macro and microcirculatory changes at the thoracic anastomosis site and followed up for any post operative anastomotic leaks.

NCT ID: NCT03723902 Completed - Aging Clinical Trials

The Effect of Strength Training and Protein Supplementation in Old Pre-frail Individuals

Start date: July 1, 2015
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effects of a lower-body strength training regime combined with protein supplementation in pre-frail elderly individuals. Participants are randomized to a group performing three weekly sessions of heavy-load strength training for 10 weeks and receiving daily protein supplementation, or a non-training, non-supplemented control group. The endpoints are changes in body composition, the relative changes in different compartments of the quadriceps femoris muscles, and the relationships between changes in muscle mass, muscle thickness, strength, and functional capacity. We hypothesize that 10 weeks of heavy load strength training and protein supplementation will elicit improvements in muscle mass, strength, and functional performance. Moreover, we hypothesize that improvements in strength will correlate with the improvements in functional performance.