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NCT ID: NCT01009593 Terminated - Neoplasms Clinical Trials

Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)

Start date: January 2010
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to assess the overall survival (OS) of oral linifanib given as monotherapy once daily (QD) compared to sorafenib given twice daily (BID) per standard of care in subjects with advanced or metastatic HCC.

NCT ID: NCT01006252 Terminated - Melanoma Clinical Trials

A Study of Tasisulam-sodium Versus Paclitaxel as Treatment for Metastatic Melanoma

SUMMIT-1
Start date: December 2009
Phase: Phase 3
Study type: Interventional

The primary purpose of this study was to see how tasisulam-sodium affected metastatic melanoma when compared against paclitaxel as measured by overall survival.

NCT ID: NCT00998764 Terminated - Alzheimer Disease Clinical Trials

A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease Patients

Start date: December 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab in subjects with Alzheimer Disease who participated in study 3133K1-3001(NCT00676143). Over 250 sites will participate in over 26 countries. Subjects will receive bapineuzumab. Each subject's participation will last approximately 4 years.

NCT ID: NCT00996918 Terminated - Alzheimer Disease Clinical Trials

A Long-Term Safety And Tolerability Study Of Bapineuzumab In Alzheimer Disease Patients

Start date: December 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab in subjects with Alzheimer Disease who participated in study 3133K1-3000 (NCT00667810). Over 250 sites will participate in over 26 countries. Subjects will receive bapineuzumab. Each subject's participation will last approximately 4 years.

NCT ID: NCT00994214 Terminated - Acromegaly Clinical Trials

Study to Assess the Efficacy and Safety of Repeated Administration of BIM 23A760 in Patients With Acromegaly

TULIPIA
Start date: October 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy of repeated subcutaneous (under the skin) injections at different doses of BIM 23A760 on growth hormone and insulin-like growth factor-1 levels in patients with acromegaly after 6 months of treatment.

NCT ID: NCT00989820 Terminated - Osteoradionecrosis Clinical Trials

Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis

Start date: October 2009
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether hyperbaric oxygen therapy is effective in the treatment of osteoradionecrosis (late damage after radiotherapy) of the jaw.

NCT ID: NCT00988052 Terminated - Clinical trials for Relapsing Multiple Sclerosis

A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course

Start date: November 10, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to make laquinimod 0.6 mg available for all subjects who completed the placebo-controlled MS-LAQ-301 study according to the protocol and to evaluate the long-term safety, tolerability and effect on disease course of daily oral laquinimod 0.6 mg in subjects with relapsing multiple sclerosis.

NCT ID: NCT00986258 Terminated - Pain Clinical Trials

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability

Start date: October 30, 2009
Phase: Phase 3
Study type: Interventional

The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III analgesics and show lack of tolerability. This is a clinical effectiveness trial designed to establish a link between anticipated clinical outcomes and the clinical practice by means of selected measures of clinical and subject-reported outcome. The trial will compare the effectiveness of previous analgesic treatment (WHO Step III) with that of tapentadol hydrochloride prolonged release treatment during defined periods of evaluation.

NCT ID: NCT00983151 Terminated - Clinical trials for Premature Ejaculation

Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation

Start date: August 2009
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to test an experimental drug therapy called Tramadol Hydrochloride (HCl) Orally Disintegrating Tablets (ODT) ("Tramadol HCl ODT" or the "study drug"). The subject and his partner are being asked to be in this clinical trial because they have a condition called premature ejaculation.

NCT ID: NCT00981799 Terminated - Clinical trials for Relapsed T-Cell Lymphoblastic Lymphoma

Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL

Start date: June 2010
Phase: Phase 1/Phase 2
Study type: Interventional

Nelarabine has shown significant activity in patients with T-cell malignancies. This study will determine the safety and maximum tolerated dose of the combination of nelarabine, cyclophosphamide and etoposide in patients with first bone marrow relapse of T-ALL, or first relapse of T-LL.