Clinical Trials Logo
  1. Home
  2. Osteoradionecrosis
  3. NCT00989820

Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis

Osteoradionecrosis Clinical Trial

Official title:
Efficacy of Adding Hyperbaric Oxygen Therapy to the Treatment of Late Radiation Damage of the Lower Jaw (Osteoradionecrosis).

Clinical Trial Summary

The purpose of this study is to determine whether hyperbaric oxygen therapy is effective in the treatment of osteoradionecrosis (late damage after radiotherapy) of the jaw.

Clinical Trial Description

Late radiation damage to the lower jaw (osteoradionecrosis (ORN)) is often seen in patients treated with radiotherapy for a tumor in the head and neck region. Part of the lower jaw becomes non-vital and has to be treated. ORN proofs to be a condition difficult to treat and the treatment for this condition varies.

In many countries hyperbaric oxygen therapy (HBOT) is added to the surgical treatment of ORN. Unfortunately there is no consensus whether the addition of hyperbaric oxygen therapy to the treatment of ORN is beneficial or not. This study has the aim to investigate the efficacy and cost-effectiveness of HBOT in the treatment of ORN ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00989820
Study type Interventional
Source Radboud University
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date October 2009
Completion date May 1, 2018
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04265430 - Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors Phase 4
Completed NCT01147315 - ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution N/A
Not yet recruiting NCT06055257 - Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible Phase 3
Recruiting NCT04934644 - The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis. N/A
Active, not recruiting NCT04009161 - Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment.
Recruiting NCT02661139 - Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction
Recruiting NCT00760682 - Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study Phase 2
Recruiting NCT05412849 - Radiation Field, Dose and Fractionation Related to Mandibular Complications
Completed NCT02368457 - Management of Mandibular ORN: PENTO as Medical Treatment Phase 4
Active, not recruiting NCT02057510 - Observational Study of Dental Outcomes in Head and Neck Cancer Patients
Active, not recruiting NCT05325970 - Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients
Completed NCT04717765 - Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention N/A