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NCT ID: NCT06460753 Completed - Clinical trials for Coronavirus Infection COVID-19

Analysis of Laboratory Markers for Severe COVID-19

Start date: April 10, 2024
Phase:
Study type: Observational

The course of coronavirus infection was often severe and required hospitalization of patients in the intensive care unit. The new SARS-Cov-2 has been poor studied, so relatively reliable markers are needed to effectively monitor patients and predict complications and outcome. Taking into account the known mechanisms of pathogenesis, the biochemical markers as ferritin, procalcitonin, C-reactive protein and D-dimer were chosen for this purpose. Patients were divided according to the degree of pulmonary infiltration. We hypothesized that the markers would correlate with dynamics, complications, and outcomes.

NCT ID: NCT06437626 Completed - Clinical trials for Ischemic Stroke, Acute

MEXIDOL® Sequential Therapy of Patients With Acute Cerebral Failure

MIR
Start date: November 18, 2019
Phase: Phase 3
Study type: Interventional

Cerebral stroke is one of the most pressing clinical and social problems of modern medicine. According to WHO estimates, acute cerebral failure rank second among all causes of death. Optimizing the treatment of such conditions remains an urgent problem in neurology and rehabilitation.

NCT ID: NCT06410352 Recruiting - Metabolic Syndrome Clinical Trials

Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

Background. The prevalence of type 2 diabetes mellitus (T2D) in the world is constantly increasing. Treatment of T2D is complicated by arterial hypertension and obesity (metabolic syndrome - MS). Cardiovascular complications are the main cause of death in patients with MS. Objective weight loss improves clinical and laboratory parameters in patients with T2D and hypertension. Purpose: To study lifespan, glycemic and lipid metabolism, quality of life, and cost-effectiveness of pharmacologic, surgical, and dietetic weight loss methods in obese patients with MS at 24 weeks in a comparative clinical trial. Methods: 1. st stage - Study design: An open pilot prospective clinical trial. The study included 71 adult patients with T2D and hypertension for the Ramadan fast's (RF) weight loss. 2. nd stage - Study design: A 24-week open label, prospective, multicenter, comparative clinical trial with the intention-to-treat analysis. Participants. Totally 150 adult patients with MS aged 35-65 years and with BMI≥27 kg/m2 for Asian will be included. They will be distributed in three comparative groups: drug treatment, surgery and diet. Primary endpoints: weight loss, fasting blood glucose, blood insulin level, systolic/diastolic BP. Secondary endpoints: blood lipids, heel bone mineral density (HBMD), and ejection fraction (EF). Expected results: A prospective multicenter clinical study will provide comparative results on life expectancy, glycemic and lipid metabolism, quality of life, cost-effectiveness of pharmacological, bariatric and dietary methods of weight loss in patients with obesity, T2D and hypertension. As a result of the research, the following will be published: 1. at least three articles and/or reviews in peer-reviewed scientific publications indexed in the Science Citation Index Expanded of the Web Of Science database and/or having a Cite Score percentile in the Scopus of at least 50; 2. at least 1 patent for an invention (including a positive decision on it).

NCT ID: NCT06397430 Completed - Postoperative Clinical Trials

Nutritional Support for Patients Operated for Malignant Tumors in HPD Zone

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

A comprehensive comparative analysis of the effectiveness of isolated enteral, isolated parenteral and mixed type of nutritional support in the early postoperative period in patients after operations performed on the malignant neoplasms of hepatico-pancreatico-duodenal zone.

NCT ID: NCT06344598 Recruiting - Clinical trials for Improving the Early Diagnosis of Osteoporosis in Adults and Children Living in the Abay Region of Kazakhstan

Identification and Assessment of Risk Factors for the Development of Osteoporosis in Adults and Children Living in the Abay Region of the Republic of Kazakhstan Using the Method of Dual-energy X-ray Absorptiometry and Clinical and Epidemiological Research

Start date: September 1, 2023
Phase:
Study type: Observational

A survey of people to identify risk factors for osteoporosis, which include age, gender, lifestyle, diet, physical activity, the presence or absence of somatic pathology. Diagnosis of osteoporosis by dual-energy X-ray absorptiometry. Conducting a correlation analysis of the relationship of the data obtained.

NCT ID: NCT06338969 Recruiting - Obesity, Morbid Clinical Trials

The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis

Start date: March 25, 2024
Phase: N/A
Study type: Interventional

Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates. Insufficient production of ketone bodies reduces the rate of weight loss, and excessive amounts of ketones can lead to ketoacidosis or liver failure in patients with nonalcoholic steatohepatitis (NASH). The investigators hypothesize that weight loss is directly related to calorie intake, and a significant reduction in carbohydrate content leads to increased ketosis and the risk of ketoacidosis. Objectives: The study aimed to compare the incidence of ketoacidosis and liver failure in patients with NASH with different intakes of carbohydrates in the early postoperative period after gastric bypass. In addition, the investigators want to find out how carbohydrate restriction will affect weight loss for up to 1 year.

NCT ID: NCT06323096 Recruiting - Polytrauma Clinical Trials

Development of Clinical Decision Support System for Severe Patients With Polytrauma

Start date: December 1, 2020
Phase:
Study type: Observational

The goal of this observational study is to develop a Clinical Decision Support System for severe patients with polytrauma. The main questions it aims to answer are: - Is it possible to predict the development of systemic inflammatory response syndrome for the next 24 h after admission? - Is it possible to predict the development of blood loss >25% of blood volume for the next 24 h after admission? - Is it possible to predict the development of acute traumatic coagulopathy for the next 24 h after admission? - Is it possible to predict the development of pneumonia in polytrauma patients? - Is it possible to predict the outcome in polytrauma patients? No intervention is planned for this study.

NCT ID: NCT06320483 Recruiting - Clinical trials for Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)

Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period

Start date: September 20, 2023
Phase:
Study type: Observational

The goal of this observational study is to evaluate the effectiveness and safety of vibro-acoustic pulmonary therapy (VAPT) in complex therapy for the acute respiratory failure of mixed type I-II stages in comparison with percussion massage in cardiac surgical patients in the early postoperative period.

NCT ID: NCT06294795 Recruiting - Astigmatism Clinical Trials

Toric Intraocular Lens Implantation in Pediatric Cataract

TILIPC
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

To evaluate the visual and refractive outcomes after an intraocular lens (IOL) implantation in pediatric eyes with cataract and preexisting corneal astigmatism

NCT ID: NCT06273826 Recruiting - Clinical trials for Anastomotic Leak Rectum

"Colorectal Leakage App" for Early Detection of Anastomotic Leakage After Colorectal Surgeries

Start date: January 19, 2024
Phase:
Study type: Observational [Patient Registry]

The aim of this prospective observational study is to evaluate the effectiveness of the mobile application "Colorectal Leakage App" in the early diagnosis of anastomotic leakage after colorectal surgeries at the National Research Oncology Center in Astana, Kazakhstan. Main Questions: 1. Development, validation, and implementation of the mobile application "Colorectal Leakage App," based on the Dutch Leakage Score. 2. Evaluate the diagnostic effectiveness of the application in detecting anastomotic leakage after colorectal surgeries. 3. Determine the frequency of anastomotic leakage after colorectal surgeries performed in the colorectal surgery sector of the National Research Oncology Center in the Astana city. Participants in the study, individuals aged 18 and above undergoing colorectal surgeries, will be monitored by the mobile application "Colorectal Leakage App" in the postoperative period for early identification of anastomotic leakage.