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NCT ID: NCT05431218 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Association of Cathelicidin and Vitamin D Levels With the Category and Course of COPD

Start date: February 18, 2020
Phase: Phase 4
Study type: Interventional

Recruitment of patients with COPD. Assessment of clinical status, determination of vitamin D and cathelicidin levels. In the group with vitamin D deficiency, patients receive cholecalciferol (vitamin D) daily for 3 months. After 3 months, the clinical status was assessed again, the level of vitamin D and cathelicidin was determined. When vitamin D levels normalize, cholecalciferol replacement therapy is discontinued for 3 months. After that, a control inspection and laboratory tests are performed.

NCT ID: NCT05427994 Recruiting - Clinical trials for Age-Related Macular Degeneration

Assessing the Quality of Life and Social Support in Age-Related Macular Degeneration Patients

Start date: April 5, 2021
Study type: Observational

The aim of this study is to evaluate the quality of life of AMD patients related to vision using the short version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), patients' social support, and their relationship with demographic and clinical variables.

NCT ID: NCT05375331 Recruiting - Child Development Clinical Trials

Clinical and Genetic Markers of Bone Metabolism in Children Under One Year

Start date: December 31, 2020
Study type: Observational

The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.

NCT ID: NCT05296655 Completed - Clinical trials for Gastro Esophageal Reflux Disease

Kazakh Version of Reflux Symptom Index

Start date: March 1, 2020
Study type: Observational

Reflux symptoms index (RSI) were developed to identify a clinical index of suspicion for laryngopharyngeal reflux (LPR) in patients with ear, nose, and throat symptoms. RSI is an efficient diagnostic tool for LPR/ It is easy to use, even for those who know little about LPR. It does not require special equipment or examinations and is inexpensive. Thus, it can be considered highly efficient and cost-effective. The study will focus on translating and testing the RSI into Kazakh language and comparing its results in healthy people and people with laryngopharyngeal reflux.

NCT ID: NCT05262088 Recruiting - Cerebral Palsy Clinical Trials

Prognostic Value of Generalized Movements in the Diagnosis of Neurological Diseases in Children

Start date: January 1, 2021
Study type: Observational

To study of the evolution of general movements in children, to develop criteria for early diagnosis of neurological disorders to reduce early neurological disability. It is observational longitudinal analytical cohort study.

NCT ID: NCT05229822 Recruiting - Colorectal Cancer Clinical Trials

Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction

Start date: March 1, 2021
Study type: Observational

Despite modern approaches to the diagnosis and treatment of acute bowel obstruction (ABO), postoperative mortality ranges from 5 to 32%, and complications occur up 23% of cases. One of the formidable infectious and inflammatory complications of ABO is sepsis. The main component of the development of sepsis in ABO is bacterial translocation (BT). BT is the migration of intestinal bacteria or their products through the intestinal mucosa into the mesenteric lymph nodes and further into normally sterile tissues and organs. Today there are several methods for detecting BT: 1. direct method - the detection of 16s rRNA (ribosomal ribonucleic acid) in mesenteric lymph nodes (MLN); 2. indirect method - the detection of serum lipopolysaccharide-binding protein (LBP) and presepsin (Soluble CD14 subtype or sCD14-ST). The aim of this study is to determine the diagnostic and prognostic significance of bacterial translocation as a predictor of the complications development in patients with malignant and benign acute bowel obstruction by assessing the relationship of biomarkers in the systemic circulation (LBP, sCD14-ST) with the detection of microorganism genes (16s rRNA) in mesenteric lymph nodes.

NCT ID: NCT05222893 Recruiting - Clinical trials for Post-Op Complication

Optimization of PEEP During Laparoscopic Surgery

Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Lung-protective ventilation (LPV) during general anesthesia can trigger the development of early postoperative pulmonary complication (PPC) and ventilator associated lung injury. One of the proven components of the LPV is low tidal volume (TV). Data on the positive end-expiratory pressure (PEEP) parameters adjustment in laparoscopic surgery, as well as the effects on the respiratory biomechanics, lung tissue and respiratory muscles damage are limited and not clear. The objective of the study is to evaluate the ability of the esophageal pressure (Pes) based controlled personalized PEEP adjustment, to improve the biomechanics of the respiratory system and oxygenation due to laparoscopic cholecystectomy.

NCT ID: NCT05189327 Recruiting - Clinical trials for Ulcerative Colitis Chronic

Noninterventional Observational Prospective Longitudinal Study of the Incidence of Ulcerative Colitis and Crohn's Disease Among the Adult Population of the Republic of Kazakhstan

Start date: December 10, 2021
Study type: Observational [Patient Registry]

The NUCaCD study aims to develop a reliable registry of patients suffering inflammatory bowel diseases in the Republic of Kazakhstan.

NCT ID: NCT05188482 Completed - Clinical trials for SARS CoV 2 Infection

Using Vibroacoustic Therapy in a Patient With Co-infection and COVID-19

Start date: September 29, 2020
Study type: Observational [Patient Registry]

This article describes a case of successful treatment of a 59-year-old man with sepsis as a result of periprosthetic infection against the background of severe SARS-CoV-2-19, who was hospitalized for 59 days, 57 of which were in the intensive care unit. Vibroacoustic pulmonary therapy, the concept of noninvasive ventilation, syndrome therapy, combination antibiotic therapy taking into account the pathogen and antibiotic sensitivity were used in the treatment.

NCT ID: NCT05179434 Recruiting - Clinical trials for Kidney Transplantation

A Study of Retrograde Reperfusion of Renal Graft to Reduce Ischemic-reperfusion Injury

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

To evaluate whether retrograde venous reperfusion of a renal graft before antegrade arterial reperfusion can reduce ischemic-reperfusion injury. All registered eligible candidates for kidney transplant will be randomized to receive either: - retrograde venous, then arterial reperfusion or - antegrade arterial reperfusion.