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NCT ID: NCT04834635 Recruiting - Obesity, Morbid Clinical Trials

The FundoRingOAGB Versus Non-wrapping (Non-banded) Standard Method of Laparoscopic One Anastomosis Gastric Bypass

FundoRingMGB
Start date: March 29, 2021
Phase: N/A
Study type: Interventional

Currently, one anastomosis gastric bypass (OAGB) or mini-gastric bypass (MGB) is a common bariatric procedure for treating obesity. Weight gain after surgery is a big problem in bariatric practice. Therefore, adjustable bands and rings are used, for example, "FobiRing". But foreign material can cause complications - the erosion of the stomach wall. For this reason, surgeons avoid the use of various mechanical devices on living tissues. The greatest criticism is of the OAGB for the likelihood of biliary reflux. In case of reflux of bile into the esophagus after surgery, as a rule, a second operation is required with conversion OAGB to the Roux-en-Y method. In addition, along with obesity, gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. In these cases, most often in bariatric practice, hiatus cruroraphy is performed, and less often fundoplication using the fundus of the excluded part of the stomach. We hypothesize that total fundoplication can not only treat GERD but also significant prevent the return of weight like after a banded gastric bypass and prevent postoperative bile reflux in the esophagus. The aim study is to compare primary outcome as weight loss after total wrapping of the fundus of the gastric excluded part (FundoRing) and non - wrapping (non - banded) standard method of laparoscopic one anastomosis gastric bypass and measure secondary outcome: bile reflux in the esophagus and GERD symptoms. Methods: Adult participants (n=100) are randomly allocated to one of two groups: Experimental surgical bariatric procedure in the first (A) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass with the total wrapping of the fundus of gastric excluded part and suture cruroplasty if present hiatal hernia (FundoRingOAGB group); Active comparator surgical bariatric procedure in the second (B) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass and with only suture cruroplasty if present hiatal hernia (OAGB group).

NCT ID: NCT04828733 Recruiting - Obesity Clinical Trials

Laparoscopic Gastric Bypass With the Total Wrapping of the Fundus of Gastric Excluded Part for Treating Obesity and GERD

Start date: March 29, 2021
Phase: N/A
Study type: Interventional

Background and study aims: Currently, one anastomosis Gastric Bypass/Mini Gastric Bypass (OAGB/MGB) is a common bariatric procedure. Obesity and gastroesophageal reflux disease are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. In these cases, most often, hiatus cruroraphy is performed, and less often fundoplication using the fundus of the excluded part of the stomach. We hypothesize that total fundoplication can not only treat GERD but also prevent the return of weight like a banded gastric bypass. The aim study is to compare bariatric and antireflux results after OAGB/MGB plus suture cruroplasty (SCP) with and without total fundoplication. Methods: Adult participants (n=100) are randomly allocated to one of two groups: Experimental surgical bariatric procedure in the first (A) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass with the total wrapping of the fundus of gastric excluded part and suture cruroplasty (OAGB + SCP + TF group); Active comparator surgical bariatric procedure in the second (B) group: patients (n=50) undergo the laparoscopic one anastomosis gastric bypass with only suture cruroplasty (OAGB + SCP group). All patients are then followed up 12, 24, 36 months after surgery where record the changing body mass index and change of GERD symptoms (GERD-HRQL).

NCT ID: NCT04779853 Recruiting - Pertussis Clinical Trials

Seroprevalence of Pertussis Among Healthy Children and Adolescents in Kazakhstan

Start date: January 25, 2021
Phase:
Study type: Observational

Seroprevalence of pertussis among older children and adolescents in Kazakhstan: A cross sectional study. Justification: to describe the distribution of anti-pertussis toxin (PT) antibodies (IgA and IgG) in a population aged 10-18 years old according to sociodemographic characteristics, vaccination history, and risk factors of pertussis infection.

NCT ID: NCT04771221 Enrolling by invitation - Clinical trials for Gastro Esophageal Reflux

Method of Early Diagnosis of Laryngopharyngeal Reflux

LPR
Start date: April 10, 2021
Phase: N/A
Study type: Interventional

The investigator will issue a Patient Information Consent for the participant in the study. 1.Patients will be asked to complete the Reflux Symptom Index questionnaire. Clinical survey, medical history 2. Objective methods for assessing the patient's condition: - examination of ENT organs: rhinoscopy, otoscopy, pharyngoscopy and laryngoscopy 3. Laboratory and instrumental research methods - Endoscopic laryngoscopy and video laryngoscopy. pH-metry: The collection of mucus from the laryngopharynx for the determination of acid-base values. 4.Sociological method: determination of lifestyle, nutrition, the presence or absence of bad habits. 5. Subjective methods for assessing the condition of the larynx - Questionnaires. 6. đÉnalysis of the received data

NCT ID: NCT04762849 Not yet recruiting - Obesity Clinical Trials

A Banded One Anastomosis Gastric Bypass With Use Shape-memory Ring Versus Non-banded One Anastomosis Gastric Bypass

MEMORING
Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Background and study aims: Currently, the gastric bypass is increasingly performed in the version of the mini gastric bypass (MGB). Another name for the procedure: one anastomosis gastric bypass (OAGB). Insufficient weight loss after bariatric surgery or weight gain after surgery is a common big problem in weight loss surgery. The use of unregulated and uncontrolled bands and rings is not always effective according to previous studies. This study compares the loss of weight after the laparoscopic banded one anastomosis gastric bypass with the use of a shape-memory ring and standard laparoscopic one anastomosis gastric bypass. Methods: Adult participants (n=100) are randomly allocated to one of two groups: Experimental surgical bariatric procedure in the first (A) group: patients (n=50) will undergo the laparoscopic banded one anastomosis gastric bypass with use of a shape-memory ring (MGB/OAGB+SMR group); Active comparator surgical bariatric procedure in the second (B) group: patients (n=50) will undergo the laparoscopic one anastomosis gastric bypass (MGB/OAGB group) without band: standard surgery. All patients are then followed up 12, 24, 36 months after surgery where record the changing body mass index.

NCT ID: NCT04734483 Recruiting - Larynx Disease Clinical Trials

The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.

NCT ID: NCT04727775 Recruiting - Pneumonia, Viral Clinical Trials

Antiviral Drugs on the Treatment of SARS-CoV-2

FavRem
Start date: November 25, 2020
Phase: Phase 1
Study type: Interventional

Retrospective Non-Randomized Analytical Cohort Study of Completed SARS-CoV2 COVID19 Cases

NCT ID: NCT04702685 Not yet recruiting - Pain, Postoperative Clinical Trials

Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery

Start date: January 2021
Phase: Phase 3
Study type: Interventional

Prospective, single-centre, randomized, controlled, open-label, evaluator-blinded, superiority trial.

NCT ID: NCT04691908 Active, not recruiting - Covid19 Clinical Trials

Immunogenicity, Efficacy and Safety of QazCovid-in® COVID-19 Vaccine

Start date: December 25, 2020
Phase: Phase 3
Study type: Interventional

Multicenter, randomized, blind, placebo-controlled clinical study of III phases on the assessment of preventive efficiency, safety and immunogenicity QazCovid-in®-vaccine against COVID-19 in healthy adult volunteers

NCT ID: NCT04632823 Recruiting - Type 2 Diabetes Clinical Trials

"The Effect of Comprehensive Non-pharmacological Treatment on Metabolic Disorders in Type 2 Diabetic Patients"

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Evaluation of the effectiveness of comprehensive non-pharmacological treatment on metabolic disorders in type 2 diabetic patients