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NCT ID: NCT04588428 Completed - Clinical trials for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

Safety, Tolerability and Immunogenicity of INO-4700 for MERS-CoV in Healthy Volunteers

Start date: June 21, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this Phase 2a, randomized, blinded, placebo-controlled, multi-center study is to evaluate the safety, tolerability and immunogenicity of INO-4700 administered by intradermal (ID) injection followed by electroporation (EP) using the CELLECTRAâ„¢ 2000 device in healthy adult volunteers for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. This study is divided into 2 parts: Part 1- dose finding stage and Part 2- dose expansion stage.

NCT ID: NCT04565873 Completed - Pregnancy Related Clinical Trials

Thyroid Stimulating Hormone (TSH) Level Variations in Early Pregnancy

Start date: January 1, 2014
Phase:
Study type: Observational

Retrospective comparative study comparing group 1 (TSH level 0.1-1.99 mIU/L) and group 2 (TSH level 2.0-4 mIU/L). Each group was further subdivided into primigravidae and multipara. 1527 pregnant women were included.

NCT ID: NCT04549987 Completed - Clinical trials for Orthodontic Appliance

Speed of Premolar Extraction Space Closure: Every Visit Replacement of Working Archwire

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The aims of this trial were to assess the effect of changing 0.019X0.025-inch SS working archwire monthly on the rate of space closure, to compare the frictional resistance of unchanged and new working archwires in-vitro, and to assess its effect on the rate of space closure, to record the amount of ion concentration in the saliva before orthodontic treatment, before space closure and one month after space closure.

NCT ID: NCT04549948 Completed - Clinical trials for Orthodontic Treatment

Curve of Spee: Speed of Leveling Using Different Orthodontic Archwires

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The objectives if this study was to evaluate the efficacy of 3 different rectangular archwires in the correction of the curve of Spee (COS), to record the time needed to level excessive COS in the mandibular arch using the 3 archwire sizes, to investigate the changes in intercanine and intermolar widths and arch length during leveling, to measure the arterio-posterior and vertical movement for the lower incisors and lower molars, to record pulpal blood flow and to detect the root resorption in the lower anterior teeth associated with leveling excessive COS using the 3 different archwires.

NCT ID: NCT04518930 Completed - Body Weight Clinical Trials

High Fat vs High Protein and Appetite Hormones

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

This study will investigate the effects of high-protein, high-fat snacks, specifically Greek yogurt, and peanuts, on satiety, gut hormones, and insulin secretion in overweight and obese women. The hypothesis posited that peanuts will exhibit a more beneficial impact on satiety, gut hormones, and insulin levels compared to Greek yogurt. The two-arm parallel randomized trial will involve 52 participants aged 30 to 40 with a BMI between 25-35 kg/m²,and they will be randomly divided into peanut (n=26) and Greek yogurt (n=26) groups. Pre-snack, BMI and dietary intake will be assessed. Appetite sensations will be gauged using a visual analog scale (VAS) upon arrival, and at 30- and 60-minutes post-snack. Pre- and post-snacking, plasma levels of cholecystokinin (CCK), Peptide Tyrosine-Tyrosine (PYY), Glucagon Like Peptide-1 (GLP-1), Ghrelin (GHRL), and insulin will be analyzed.

NCT ID: NCT04514887 Completed - Clinical trials for Laparoscopic Gastric Sleeve Surgery

Mild Intraoperative Hyperventilation to Decrease Post-op. Shoulder Pain After LSG

Start date: June 16, 2019
Phase: N/A
Study type: Interventional

Shoulder pain is common after laparoscopic surgeries. multiple maneuvers are in use to decrease its incidence with variable results. This study aims to investigate the effect of mild hyperventilation to an End-tidal CO2 level of 30-32 mmHg on the occurrence of postoperative shoulder pain. This is carried out through a comparison of the incidence of postoperative shoulder pain an intervention group to that in a control one with a normal End Tidal CO2 35-40 mmHg). controlling for all other variables.

NCT ID: NCT04510207 Completed - COVID-19 Clinical Trials

A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above

COVID-19
Start date: July 16, 2020
Phase: Phase 3
Study type: Interventional

This is a multicenter, randomized, double blind, parallel placebo controlled, phase 3 clinical trial to evaluate the protective efficacy, safety and immunogenicity of inactivated SARS-CoV-2 vaccines in healthy population 18 years old and above.

NCT ID: NCT04483271 Completed - Cytokine Storm Clinical Trials

The Effect of Omega-3 on Selected Cytokines Involved in Cytokine Storm

Start date: October 2, 2020
Phase: N/A
Study type: Interventional

The trial was designed to assess the effect of daily dose of 300 mg omega-3 supplements for 2 months on the selected interleukins levels in uninfected people with Covid-19.

NCT ID: NCT04476745 Completed - Cytokine Storm Clinical Trials

The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People

Start date: October 5, 2020
Phase: N/A
Study type: Interventional

The effect of Weekly 50,000 IU vitamin D3 supplements on the serum levels of selected cytokines involved in cytokine storm of Covid-19; A randomized clinical trial in the Covid-19 uninfected people with vitamin D deficiency.

NCT ID: NCT04468165 Completed - Clinical trials for Relapsing Remitting Multiple Sclerosis

Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region

Start date: February 23, 2021
Phase:
Study type: Observational

The purpose of this observational study is to evaluate the effectiveness, safety and health related quality of life of Generic DMF (Sclera® or Marovarex ®, Hikma) in patients undergoing routine clinical care for RRMS in MENA Region