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NCT ID: NCT04824586 Completed - Diabetes Mellitus Clinical Trials

Intraoperative Insulin Administration at Cardiac Surgery for Diabetic Patients

Start date: June 1, 2019
Phase: Phase 4
Study type: Interventional

The primary objective of the study was to explore which insulin-based regimen is better, infusion or bolus regimen, for intraoperative management of glucose level for the diabetic patient at cardiac surgery. Secondary objectives include: comparing the relative amounts of insulin needed during the operation and subsequent cost impact and comparing potassium levels between groups. Ethical approval for the study was obtained from the Office for Research Ethics Committees at Hashemite University - Prince Hamza hospital. This study was a parallel-group, randomized, controlled trial with 1:1 allocation ratio. Participants: Adult diabetic patients, type 2, who were admitted to hospital for cardiac surgery. The intervention: Both patients in the infusion or bolus group received their dose of insulin, fast-acting human insulin (Actrapid®) was used. Setting: Patients were recruited at Prince Hamza hospital, Amman, Jordan. A tertiary care center specialized unit in cardiac surgery for diabetic patients. Outcomes monitoring: It was monitored six times as follows: preoperative induction measure, then glucose post heparin, and after that for 2 hours, glucose levels were monitored every 30 minutes. Insulin quantities were recorded as well to be used in secondary outcomes analysis. Randomization, allocation, and blinding During patient enrolment, concealed allocation to either infusion group or bolus group was guaranteed through the use of a closed envelope system prepared by an independent investigator. Block randomization with random block sizes, ensured allocation balance, and avoided selection bias by preventing allocation prediction. Researchers and physicians were blind to the block size sequence and randomization. Envelopes were unopened until completion of patient registration. Hospital staff who monitor glucose and those who administered insulin were blinded to the primary and secondary outcomes' measure.

NCT ID: NCT04821804 Completed - Clinical trials for Gingival Recession, Plastic Surgery

Local Application of Hyaluronic Acid (HYADENT BG) With Free Soft Tissue Grafing Improves Treatment Outcomes.

Start date: January 2, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

A total of 24 healthy non-smoker patients requiring FGG recruited for the study. Subjects were equally and randomly assigned into two groups. Test group, local application of HYADENT BG on both donor and recipient sites. Control group, application of normal saline on both sites as placebo. The FGG dimensions were evaluated at 1, 3- and 6-month recall using digital photographs. Post-operative pain was evaluated for 14 days. Color matching and patient satisfaction were evaluated at 6 months.

NCT ID: NCT04815213 Recruiting - Clinical trials for Premature Ovarian Failure

The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans

Start date: January 1, 2020
Phase: Phase 1
Study type: Interventional

Autologous bone marrow-derived mesenchymal cells will be injected into patients diagnosed with premature ovarian failure

NCT ID: NCT04815135 Completed - Emergencies Clinical Trials

Effect of Covid-19 Pandemic on Emergency Surgery Practice

Start date: March 1, 2019
Phase:
Study type: Observational

A retrospective study at a tertiary university hospital to determine the effect of the COVID-19 pandemic on the emergency surgery practice in the hospital.

NCT ID: NCT04810000 Completed - Clinical trials for Arthroplasty Complications

The Effect of Releasing the Tourniquet in Total Knee Replacement Before Closure on the Blood Loss , Joint Effusion , Hematoma Formation and Wound Complication

Start date: December 3, 2018
Phase:
Study type: Observational [Patient Registry]

The study , observe the effect of releasing the Tourniquet in total knee replacement surgery before closure in comparison with releasing it after wound closure The effect was assessed by Hb drop post operative and Hematoma formation ( measured by ultrasound ) as well as the wound complication

NCT ID: NCT04779528 Not yet recruiting - Anesthesia Clinical Trials

Awake Nasal Fiber-optic Intubation of Severely Obese Patients in Lateral Position

Start date: March 2021
Phase: N/A
Study type: Interventional

Airway management in severely obese patients remains a challenging issue for anesthetists and may lead to life-threatening situations. Awake Fiber-Optic Bronchoscopy Intubation (FOBI) technique is considered as the gold standard when a difficult airway is anticipated to secure the airway and to facilitate the surgery. FOBI is usually done in supine position, while (in conscious patients) lateral position is the most recommended position to keep the upper airway patent. This prospective clinical trial study will test whether awake FOBI in Lateral position will provide a safe profile or a significant advantage over FOBI in supine position, in morbidly obese patients undergoing elective bariatric surgery.

NCT ID: NCT04779515 Completed - Pain Clinical Trials

Effect of Low-pressure Pneumoperitoneum on Pain and Inflammation Post Laparoscopic Cholecystectomy

Start date: January 20, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.

NCT ID: NCT04759638 Completed - Rectal Cancer Clinical Trials

Short Running Head Obesity in Rectal Cancer Patients

Start date: March 21, 2017
Phase:
Study type: Observational

There is a controversy regarding the effect of the two Body Mass Index (BMI) extremes on the oncological outcome of rectal cancer. The obesity paradox appears to exist in rectal cancer patients treated with nCRT and surgery, as it was associated with significantly higher rates of pathological complete response and R0 resection. Underweight patients were at higher risk for anastomotic leak and R1 resection.

NCT ID: NCT04756102 Completed - Maternal Diabetes Clinical Trials

Glucose Levels in Early Pregnancy and Feto-maternal Outcome

Start date: January 30, 2018
Phase:
Study type: Observational

to find out whether variations in the fasting blood glucose in early pregnancy affect the fetomaternal outcome

NCT ID: NCT04747184 Completed - Asthma Clinical Trials

Variations in the Composition of Respiratory Microbiota

Start date: December 1, 2019
Phase:
Study type: Observational

Induced sputum samples were obtained from 27 asthmatic patients and 27 non-asthmatic subjects. Sequencing of the V4 region of 16S rRNA gene using Illumina MiSeq was performed, followed by analysis of alpha and beta diversity.